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Disentangling Signatures of Selection Before and After European Colonization in Latin Americans

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dc.contributor.author Mendoza-Revilla, J.
dc.contributor.author Chacón-Duque, J.C.
dc.contributor.author Fuentes-Guajardo, M.
dc.contributor.author Ormond, L.
dc.contributor.author Wang, K.
dc.contributor.author Hurtado, M.
dc.contributor.author Villegas, V.
dc.contributor.author Granja, V.
dc.contributor.author Acuña-Alonzo, V.
dc.contributor.author Jaramillo, C.
dc.contributor.author Arias, W.
dc.contributor.author Barquera, R.
dc.contributor.author Gómez-Valdés, J.
dc.contributor.author Villamil-Ramírez, H.
dc.contributor.author Silva de Cerqueira, C.C.
dc.contributor.author Badillo Rivera, K.M.
dc.contributor.author Nieves-Colón, M.A.
dc.contributor.author Gignoux, C.R.
dc.contributor.author Wojcik, G.L.
dc.contributor.author Moreno-Estrada, A.
dc.contributor.author Hünemeier, T.
dc.contributor.author Ramallo, V.
dc.contributor.author Schuler-Faccini, L.
dc.contributor.author Gonzalez-José, R.
dc.contributor.author Bortolini, M.-C.
dc.contributor.author Canizales-Quinteros, S.
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Poletti, G.
dc.contributor.author Bedoya, G.
dc.contributor.author Rothhammer, F.
dc.contributor.author Balding, D.
dc.contributor.author Fumagalli, M.
dc.contributor.author Adhikari, K.
dc.contributor.author Ruiz-Linares, A.
dc.contributor.author Hellenthal, G.
dc.date.accessioned 2022-06-01T13:53:58Z
dc.date.available 2022-06-01T13:53:58Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11759
dc.description.abstract Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insights, the extent to which this process contributed to adaptation remains underexplored. Here, we introduce a novel statistical model, specific to admixed populations, that identifies loci under selection while determining whether the selection likely occurred post-admixture or prior to admixture in one of the ancestral source populations. Through extensive simulations, we show that this method is able to detect selection, even in recently formed admixed populations, and to accurately differentiate between selection occurring in the ancestral or admixed population. We apply this method to genome-wide SNP data of ∼4,000 individuals in five admixed Latin American cohorts from Brazil, Chile, Colombia, Mexico, and Peru. Our approach replicates previous reports of selection in the human leukocyte antigen region that are consistent with selection post-admixture. We also report novel signals of selection in genomic regions spanning 47 genes, reinforcing many of these signals with an alternative, commonly used local-ancestry-inference approach. These signals include several genes involved in immunity, which may reflect responses to endemic pathogens of the Americas and to the challenge of infectious disease brought by European contact. In addition, some of the strongest signals inferred to be under selection in the Native American ancestral groups of modern Latin Americans overlap with genes implicated in energy metabolism phenotypes, plausibly reflecting adaptations to novel dietary sources available in the Americas. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Molecular Biology and Evolution
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Natural selection en_US
dc.subject Latin Americans en_US
dc.subject Native Americans en_US
dc.subject Admixture en_US
dc.title Disentangling Signatures of Selection Before and After European Colonization in Latin Americans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/molbev/msac076
dc.relation.issn 1537-1719


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