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Quality of life in patients with symptomatic epilepsy due to neurocysticercosis

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dc.contributor.author Zapata, Willy R.
dc.contributor.author Yang, Susan Y.
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author Gonzales, Isidro
dc.contributor.author Saavedra Pastor, Herbert
dc.contributor.author Guzman, Carolina
dc.contributor.author Pretell, E.Javier
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author for The Cysticercosis Working Group In Peru
dc.date.accessioned 2022-06-25T20:36:42Z
dc.date.available 2022-06-25T20:36:42Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11871
dc.description.abstract Background: Neurocysticercosis (NCC) is a common cause of late-onset epilepsy worldwide, but there is still minimal information regarding its impact on a patient's quality of life. This study evaluated quality of life in a series of patients with epilepsy secondary to NCC using the QOLIE (Quality of Life in Epilepsy)-31 questionnaire. Methodology: This cross-sectional study included 155 Peruvian patients between 16 and 70 years of age with epilepsy due to viable intraparenchymal NCC, who enrolled in two trials of anti-parasitic treatment during the period 2006–2011. The QOLIE-31 questionnaire was applied before the onset of anti-parasitic treatment. The associations between QOLIE-31 scores, sociodemographic characteristics, clinical, and neuroimaging data were analyzed with Kruskal–Wallis test and generalized linear models (GLM). Results: The average QOLIE-31 score was 55.8 (SD ± 7.6), with 119 individuals (76.8%) scoring in the poor quality-of-life category. Generalized tonic-clonic seizures and secondarily generalized epileptic seizures were associated with a lower QOLIE-31, as well as a low level of education with a value of p = 0.05. There were no associations between QOLIE-31 scores and other variables such as sex, age, antiepileptic medication, number of parasitic cysts, and number of compromised brain regions. On multivariate analysis, a greater number of generalized epileptic seizures maintained a statistically significant association with detrimental QOLIE-31 scores. Conclusion: Quality of life is affected in NCC, mainly in relation to the number of prior generalized epileptic seizures. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Epilepsy and Behavior
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Cysticercosis en_US
dc.subject Neurocysticercosis en_US
dc.subject Epilepsy en_US
dc.subject QOLIE-31 score en_US
dc.subject Quality of life en_US
dc.subject Peru en_US
dc.title Quality of life in patients with symptomatic epilepsy due to neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.yebeh.2022.108668
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn 1525-5069


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