Universidad Peruana Cayetano Heredia

Rising incidence and prevalence of systemic lupus erythematosus: a population-based study over four decades

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dc.contributor.author Duarte-Garcia, A
dc.contributor.author Hocaoglu, M
dc.contributor.author Valenzuela-Almada, M
dc.contributor.author Osei-Onomah, SA
dc.contributor.author Dabit, JY
dc.contributor.author Sanchez-Rodriguez, A
dc.contributor.author Duong, SQ
dc.contributor.author Giblon, RE
dc.contributor.author Langenfeld, HE
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Helmick, CG
dc.contributor.author Crowson, CS
dc.date.accessioned 2022-06-25T20:36:43Z
dc.date.available 2022-06-25T20:36:43Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11880
dc.description.abstract Objectives: To determine the trends in incidence, prevalence and mortality of systemic lupus erythematosus (SLE) in a US population over four decades. Methods: We identified all the patients with SLE in Olmsted County, Minnesota who fulfilled the European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria for SLE during 1976–2018. Age-specific and sex-specific incidence and prevalence dates were adjusted to the standard 2000 projected US population. The EULAR/ACR score was used as a proxy for disease severity. Standardised mortality ratio (SMR) was estimated. Results: There were 188 incident SLE cases in 1976–2018 (mean age 46.3±SD 16.9; 83% women). Overall age-adjusted and sex-adjusted annual SLE incidence per 100 000 population was 4.77 (95% CI 4.09 to 5.46). Incidence was higher in women (7.58) than men (1.89). The incidence rate increased from 3.32 during 1976–1988 to 6.44 during 2009–2018. Incidence rates were higher among the racial and ethnic minority populations than non-Hispanic whites. The EULAR/ACR score did not change significantly over time. Overall prevalence increased from 30.6 in 1985 to 97.4 in 2015. During the study period, there was no improvement in SMR over time (p=0.31). Conclusions: The incidence and prevalence of SLE are increasing in this US population. The increase in incidence may be at least partially explained by the rising ethnic/racial diversity of the population. There was no evidence that the severity of SLE has changed over time. The survival gap between SLE and the general population remains unchanged. As the US population grows more diverse, we might continue to see an increase in the incidence of SLE. en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Annals of the Rheumatic Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Correspondence en_US
dc.subject Systemic lupus erythematosus en_US
dc.subject population-based study en_US
dc.title Rising incidence and prevalence of systemic lupus erythematosus: a population-based study over four decades en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/annrheumdis-2022-222276
dc.relation.issn 1468-2060


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