Universidad Peruana Cayetano Heredia

Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol

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dc.contributor.author Curico, G
dc.contributor.author Garcia-Bardales, P
dc.contributor.author Pinedo, T
dc.contributor.author Shapiama, W
dc.contributor.author Moncada-Yaicate, M
dc.contributor.author Romaina, L
dc.contributor.author Yori, PP
dc.contributor.author Paredes-Olortegui, M
dc.contributor.author Meza-Sanchez, G
dc.contributor.author Lescano Guevara, Andres Guillermo
dc.contributor.author Paz-Soldan Parlette, Valerie Andrea
dc.contributor.author Schiaffino Salazar, Francesca
dc.contributor.author Oberhelman, RA
dc.contributor.author Kosek, MN
dc.date.accessioned 2022-06-25T20:36:43Z
dc.date.available 2022-06-25T20:36:43Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/11882
dc.description.abstract Background: Deworming programs aimed at reducing morbidity and mortality from geohelminth infections are common in many countries where these infections are endemic, but data demonstrating increasing levels of resistance to albendazole and mebendazole are causes for concern. Studies to evaluate the clinical efficacy of deworming programs are critical to maintain high infection control goals. Methods: We propose to assess the clinical efficacy of Peruvian national guidelines for deworming programs in a prospective observational study conducted in the Amazon River basin area near Iquitos, Peru. Major outcomes to be evaluated include (1) albendazole resistance of intestinal helminths (trichuriasis, ascariasis, hookworm), and (2) frequency of reinfection with intestinal helminths 4 months after treatment with albendazole. Children ages 2–11 years from the Belén District of Iquitos will be identified based on a community census. Following parental informed consent, demographic data, weight, and height will be recorded and a stool specimen for parasitological exam by direct observation and Kato-Katz concentration method, and helminthic egg counts will be collected prior to administration of albendazole, following Peruvian national guidelines. Follow-up stool specimens examined in the same manner will be collected at 20 days, 90 days, and 100 days following initial administration of albendazole, and based on parasites found repeat treatment will be administered in accordance with national guidelines. Real-time multiplex qPCR will be performed on helminth positive samples collected prior to initial deworming and on helminth-positive specimens detected on day 15–20. A total sample size of 380 participants was calculated based on total population in the target group and prevalence estimates of helminth infections and clinical resistance based on recent data. Discussion: Data from observational clinical efficacy studies are important to guide geohelminth infection control programs. en_US
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartofseries BMC Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Helminths en_US
dc.subject Deworming en_US
dc.subject Albendazole en_US
dc.subject Ivermectin en_US
dc.subject Children en_US
dc.subject Peru en_US
dc.title Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1186/s12879-022-07494-0
dc.relation.issn 1471-2334


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