Universidad Peruana Cayetano Heredia
Antiretroviral Initiation at >= 800 CD4+Cells/mm(3) Associated With Lower Human Immunodeficiency Virus Reservoir Size
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| dc.contributor.author | Rasmussen, TA | |
| dc.contributor.author | Ahuja, SK | |
| dc.contributor.author | Kuwanda, L | |
| dc.contributor.author | Vjecha, MJ | |
| dc.contributor.author | Hudson, F | |
| dc.contributor.author | Lal, L | |
| dc.contributor.author | Rhodes, A | |
| dc.contributor.author | Chang, J | |
| dc.contributor.author | Palmer, S | |
| dc.contributor.author | Auberson-Munderi, P | |
| dc.contributor.author | Mugerwa, H | |
| dc.contributor.author | Wood, R | |
| dc.contributor.author | Badal-Faesen, S | |
| dc.contributor.author | Pillay, S | |
| dc.contributor.author | Mngqibisa, R | |
| dc.contributor.author | LaRosa, A | |
| dc.contributor.author | Hildago, J | |
| dc.contributor.author | Petoumenos, K | |
| dc.contributor.author | Chiu, C | |
| dc.contributor.author | Lutaakome, J | |
| dc.contributor.author | Kitonsa, J | |
| dc.contributor.author | Kabaswaga, E | |
| dc.contributor.author | Pala, P | |
| dc.contributor.author | Ganoza, Carmela | |
| dc.contributor.author | Fisher, K | |
| dc.contributor.author | Chang, C | |
| dc.contributor.author | Lewin, SR | |
| dc.contributor.author | Wright, EJ | |
| dc.date.accessioned | 2022-06-25T20:36:43Z | |
| dc.date.available | 2022-06-25T20:36:43Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/11892 | |
| dc.description.abstract | Background: Identifying factors that determine the frequency of latently infected CD4+ T cells on antiretroviral therapy (ART) may inform strategies for human immunodeficiency virus (HIV) cure. We investigated the role of CD4+ count at ART initiation for HIV persistence on ART. Methods: Among participants of the Strategic Timing of Antiretroviral Treatment Study, we enrolled people with HIV (PWH) who initiated ART with CD4+ T-cell counts of 500–599, 600–799, or ≥ 800 cells/mm3. After 36–44 months on ART, the levels of total HIV-DNA, cell-associated unspliced HIV-RNA (CA-US HIV-RNA), and two-long terminal repeat HIV-DNA in CD4+ T cells were quantified and plasma HIV-RNA was measured by single-copy assay. We measured T-cell expression of Human Leucocyte Antigen-DR Isotype (HLA-DR), programmed death-1, and phosphorylated signal transducer and activator of transcription-5 (pSTAT5). Virological and immunological measures were compared across CD4+ strata. Results: We enrolled 146 PWH, 36 in the 500–599, 60 in the 600–799, and 50 in the ≥ 800 CD4 strata. After 36–44 months of ART, total HIV-DNA, plasma HIV-RNA, and HLA-DR expression were significantly lower in PWH with CD4+ T-cell count ≥ 800 cells/mm3 at ART initiation compared with 600–799 or 500–599 cells/mm3. The median level of HIV-DNA after 36–44 months of ART was lower by 75% in participants initiating ART with ≥ 800 vs 500–599 cells/mm3 (median [interquartile range]: 16.3 [7.0–117.6] vs 68.4 [13.7–213.1] copies/million cells, respectively). Higher pSTAT5 expression significantly correlated with lower levels of HIV-DNA and CA-US HIV-RNA. Virological measures were significantly lower in females. Conclusions: Initiating ART with a CD4+ count ≥ 800 cells/mm3 compared with 600–799 or 500–599 cells/mm3 was associated with achieving a substantially smaller HIV reservoir on ART. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Oxford University Press | |
| dc.relation.ispartofseries | Clinical Infectious Diseases | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | HIV | en_US |
| dc.subject | HIV reservoir | en_US |
| dc.subject | antiretroviral therapy | en_US |
| dc.subject | HIV cure | en_US |
| dc.title | Antiretroviral Initiation at >= 800 CD4+Cells/mm(3) Associated With Lower Human Immunodeficiency Virus Reservoir Size | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1093/cid/ciac249 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
| dc.relation.issn | 1537-6591 |
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