DSpace Repository

Early identification of patients with Chagas disease at risk of developing cardiomyopathy using 2-D speckle tracking strain: Win, Miranda prediction of Chagas cardiomyopathy

Show simple item record

dc.contributor.author Win, S.
dc.contributor.author Miranda-Schaeubinger, M.
dc.contributor.author Gustavo Durán Saucedo, R.
dc.contributor.author Carballo Jimenez, P.
dc.contributor.author Flores, J.
dc.contributor.author Mercado-Saavedra, B.
dc.contributor.author Camila Telleria, L.
dc.contributor.author Raafs, A.
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.contributor.author Bern, C.
dc.contributor.author Tinajeros, F.
dc.contributor.author Heymans, S.
dc.contributor.author Marcus, R.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Mukherjee, M.
dc.date.accessioned 2022-08-15T20:11:08Z
dc.date.available 2022-08-15T20:11:08Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12022
dc.description.abstract Background: Chagas disease is an endemic protozoan disease with high prevalence in Latin America. Of those infected, 20–30% will develop chronic Chagas cardiomyopathy (CCC) however, prediction using existing clinical criteria remains poor. In this study, we investigated the utility of left ventricular (LV) echocardiographic speckle-tracking global longitudinal strain (GLS) for early detection of CCC. Methods and results: 139 asymptomatic T. cruzi seropositive subjects with normal heart size and normal LV ejection fraction (EF) (stage A or B) were enrolled in this prospective observational study and underwent paired echocardiograms at baseline and 1-year follow-up. Progressors were participants classified as stage C or D at follow-up due to development of symptoms of heart failure, cardiomegaly, or decrease in LVEF. LV GLS was calculated as the average peak systolic strain of 16 LV segments. Measurements were compared between participants who progressed and did not progress by two-sample t-test, and the odds of progression assessed by multivariable logistic regression. Of the 139 participants, 69.8% were female, mean age 55.8 ± 12.5 years, with 12 (8.6%) progressing to Stage C or D at follow-up. Progressors tended to be older, male, with wider QRS duration. LV GLS was −19.0% in progressors vs. –22.4% in non-progressors at baseline, with 71% higher odds of progression per +1% of GLS (adjusted OR 1.71, 95% CI 1.20–2.44, p = 0.003). Conclusion: Baseline LV GLS in participants with CCC stage A or B was predictive of progression within 1-year and may guide timing of clinical follow-up and promote early detection or treatment. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries IJC Heart and Vasculature
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Chagas disease en_US
dc.subject Chagas cardiomyopathy en_US
dc.subject Echocardiography en_US
dc.subject Strain imaging en_US
dc.title Early identification of patients with Chagas disease at risk of developing cardiomyopathy using 2-D speckle tracking strain: Win, Miranda prediction of Chagas cardiomyopathy en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijcha.2022.101060
dc.relation.issn 2352-9067


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics