Universidad Peruana Cayetano Heredia

Relationship Between Anemia and Systemic Inflammation in People Living With HIV and Tuberculosis: A Sub-Analysis of the CADIRIS Clinical Trial

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dc.contributor.author Araújo-Pereira, M.
dc.contributor.author Barreto-Duarte, B.
dc.contributor.author Arriaga, Maria B.
dc.contributor.author Musselwhite, L.W.
dc.contributor.author Vinhaes, C.L.
dc.contributor.author Belaunzaran-Zamudio, P.F.
dc.contributor.author Rupert, A.
dc.contributor.author Montaner, L.J.
dc.contributor.author Lederman, M.M.
dc.contributor.author Sereti, I.
dc.contributor.author Madero, J.G.S.
dc.contributor.author Andrade, B.B.
dc.date.accessioned 2022-08-15T20:11:10Z
dc.date.available 2022-08-15T20:11:10Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12059
dc.description.abstract People with HIV (PWH) are at increased risk of developing active tuberculosis (TB), and anemia is a common complication in both conditions. Anemia in TB patients has been linked to immune activation, levels of inflammatory biomarkers in blood, and risk for HIV disease progression and death. In this study we show that anemia was associated with a more pronounced inflammatory profile in HIV-TB coinfected persons in a cohort of 159 individuals with advanced HIV disease (CD4 count < 100 cells/µL) recruited as part of a randomized clinical trial (NCT00988780). A panel of plasma biomarkers was assessed on plasma obtained prior to combination antiretroviral therapy (cART) initiation. We performed a series of multidimensional analyses including clinical variables and concentrations of inflammatory biomarkers to profile systemic inflammation of PWH with and without anemia. We observed that TB participants presented with moderately lower levels of hemoglobin than non-TB participants. These participants also presented a higher Degree of Inflammatory Perturbation (DIP) score, related to increased levels of IFN-γ and TNF. The DIP was associated with TB coinfection and anemia before cART initiation. Future mechanistic studies are warranted to assess the determinants of such associations and the implications on treatment outcomes. en_US
dc.language.iso eng
dc.publisher Frontiers Media
dc.relation.ispartofseries Frontiers in Immunology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HIV en_US
dc.subject Tuberculosis en_US
dc.subject inflammation en_US
dc.subject degree of inflammatory perturbation en_US
dc.subject anemia en_US
dc.title Relationship Between Anemia and Systemic Inflammation in People Living With HIV and Tuberculosis: A Sub-Analysis of the CADIRIS Clinical Trial en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fimmu.2022.916216
dc.relation.issn 1664-3224


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