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An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples

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dc.contributor.author Adam, I.
dc.contributor.author Alam, M.S.
dc.contributor.author Alemu, S.
dc.contributor.author Amaratunga, C.
dc.contributor.author Amato, R.
dc.contributor.author Andrianaranjaka, V.
dc.contributor.author Anstey, N.M.
dc.contributor.author Aseffa, A.
dc.contributor.author Ashley, E.
dc.contributor.author Assefa, A.
dc.contributor.author Auburn, S.
dc.contributor.author Barber, B.E.
dc.contributor.author Barry, A.
dc.contributor.author Batista Pereira, D.
dc.contributor.author Cao, J.
dc.contributor.author Chau, N.H.
dc.contributor.author Chotivanich, K.
dc.contributor.author Chu, C.
dc.contributor.author Dondorp, A.M.
dc.contributor.author Drury, E.
dc.contributor.author Echeverry, D.F.
dc.contributor.author Erko, B.
dc.contributor.author Espino, F.
dc.contributor.author Fairhurst, R.
dc.contributor.author Faiz, A.
dc.contributor.author Fernanda Villegas, M.
dc.contributor.author Gao, Q.
dc.contributor.author Golassa, L.
dc.contributor.author Goncalves, S.
dc.contributor.author Grigg, M.J.
dc.contributor.author Hamedi, Y.
dc.contributor.author Hien, T.T.
dc.contributor.author Htut, Y.
dc.contributor.author Johnson, K.J.
dc.contributor.author Karunaweera, N.
dc.contributor.author Khan, W.
dc.contributor.author Krudsood, S.
dc.contributor.author Kwiatkowski, D.P.
dc.contributor.author Lacerda, M.
dc.contributor.author Ley, B.
dc.contributor.author Lim, P.
dc.contributor.author Liu, Y.
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Lon, C.
dc.contributor.author Lopera-Mesa, T.
dc.contributor.author Marfurt, J.
dc.contributor.author Michon, P.
dc.contributor.author Miotto, O.
dc.contributor.author Mohammed, R.
dc.contributor.author Mueller, I.
dc.contributor.author Namaik-larp, C.
dc.contributor.author Newton, P.N.
dc.contributor.author Nguyen, T.-N.
dc.contributor.author Nosten, F.
dc.contributor.author Noviyanti, R.
dc.contributor.author Pava, Z.
dc.contributor.author Pearson, R.D.
dc.contributor.author Petros, B.
dc.contributor.author Phyo, A.P.
dc.contributor.author Price, R.N.
dc.contributor.author Pukrittayakamee, S.
dc.contributor.author Rahim, A.G.
dc.contributor.author Randrianarivelojosia, M.
dc.contributor.author Rayner, J.C.
dc.contributor.author Rumaseb, A.
dc.contributor.author Siegel, S.V.
dc.contributor.author Simpson, V.J.
dc.contributor.author Thriemer, K.
dc.contributor.author Tobon-Castano, A.
dc.contributor.author Trimarsanto, H.
dc.contributor.author Urbano Ferreira, M.
dc.contributor.author Vélez, I.D.
dc.contributor.author Wangchuk, S.
dc.contributor.author Wellems, T.E.
dc.contributor.author White, N.J.
dc.contributor.author William, T.
dc.contributor.author Yasnot, M.F.
dc.contributor.author Yilma, D.
dc.contributor.author MalariaGEN
dc.date.accessioned 2022-08-15T20:11:11Z
dc.date.available 2022-08-15T20:11:11Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12069
dc.description.abstract This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr, dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination. en_US
dc.language.iso eng
dc.publisher F1000 Research
dc.relation.ispartofseries Wellcome Open Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Malaria en_US
dc.subject Plasmodium vivax en_US
dc.subject Genomics en_US
dc.subject Data resource en_US
dc.subject Genomic epidemiology en_US
dc.title An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.12688/wellcomeopenres.17795.1
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.00.00
dc.relation.issn 2398-502X


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