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A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates

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dc.contributor.author Fowler, P.W.
dc.contributor.author Wright, C.
dc.contributor.author Spiers, H.
dc.contributor.author Zhu, T.
dc.contributor.author Baeten, E.M.L.
dc.contributor.author Hoosdally, S.W.
dc.contributor.author Cruz, A.L.G.
dc.contributor.author Roohi, A.
dc.contributor.author Kouchaki, S.
dc.contributor.author Walker, T.M.
dc.contributor.author Peto, T.E.A.
dc.contributor.author Miller, G.
dc.contributor.author Lintott, C.
dc.contributor.author Clifton, D.
dc.contributor.author Crook, D.W.
dc.contributor.author Walker, A.S.
dc.contributor.author Barilar, I.
dc.contributor.author Battaglia, S.
dc.contributor.author Borroni, E.
dc.contributor.author Brandao, A.P.
dc.contributor.author Brankin, A.
dc.contributor.author Cabibbe, A.M.
dc.contributor.author Carter, J.
dc.contributor.author Chetty, D.
dc.contributor.author Cirillo, D.M.
dc.contributor.author Claxton, P.
dc.contributor.author Clifton, D.A.
dc.contributor.author Cohen, T.
dc.contributor.author Coronel, Jorge
dc.contributor.author Dreyer, V.
dc.contributor.author Earle, S.G.
dc.contributor.author Escuyer, V.
dc.contributor.author Ferrazoli, L.
dc.contributor.author Gao, G.F.
dc.contributor.author Gardy, J.
dc.contributor.author Gharbia, S.
dc.contributor.author Ghisi, K.T.
dc.contributor.author Ghodousi, A.
dc.contributor.author Grandjean, Louis
dc.contributor.author Grazian, C.
dc.contributor.author Groenheit, R.
dc.contributor.author Guthrie, J.L.
dc.contributor.author He, W.
dc.contributor.author Hoffmann, H.
dc.contributor.author Hoosdally, S.J.
dc.contributor.author Martinhunt, M.
dc.contributor.author Iqbal, Z.
dc.contributor.author Ismail, N.A.
dc.contributor.author Jarrett, L.
dc.contributor.author Joseph, L.
dc.contributor.author Jou, R.
dc.contributor.author Kambli, P.
dc.contributor.author Khot, R.
dc.contributor.author Knaggs, J.
dc.contributor.author Koch, A.
dc.contributor.author Kohlerschmidt, D.
dc.contributor.author Lachapelle, A.S.
dc.contributor.author Lalvani, A.
dc.contributor.author Lapierre, S.G.
dc.contributor.author Laurenson, I.F.
dc.contributor.author Letcher, B.
dc.contributor.author Lin, W.-H.
dc.contributor.author Liu, C.
dc.contributor.author Liu, D.
dc.contributor.author Malone, K.M.
dc.contributor.author Mandal, A.
dc.contributor.author Mansjõ, M.
dc.contributor.author Matias, D.
dc.contributor.author Meintjes, G.
dc.contributor.author Mendes, F.D.F.
dc.contributor.author Merker, M.
dc.contributor.author Mihalic, M.
dc.contributor.author Millard, J.
dc.contributor.author Miotto, P.
dc.contributor.author Mistry, N.
dc.contributor.author Moore, David Alexander James
dc.contributor.author Musser, K.A.
dc.contributor.author Ngcamu, D.
dc.contributor.author Nhung, H.N.
dc.contributor.author Niemann, S.
dc.contributor.author Nilgiriwala, K.S.
dc.contributor.author Nimmo, C.
dc.contributor.author O’Donnell, M.
dc.contributor.author Okozi, N.
dc.contributor.author Oliveira, R.S.
dc.contributor.author Omar, S.V.
dc.contributor.author Paton, N.
dc.contributor.author Pinhata, J.M.W.
dc.contributor.author Plesnik, S.
dc.contributor.author Puyen, Z.M.
dc.contributor.author Rabodoarivelo, M.S.
dc.contributor.author Rakotosamimanana, N.
dc.contributor.author Rancoita, P.M.V.
dc.contributor.author Rathod, P.
dc.contributor.author Robinson, E.
dc.contributor.author Rodger, G.
dc.contributor.author Rodrigues, C.
dc.contributor.author Rodwell, T.C.
dc.contributor.author Santos-Lazaro, D.
dc.contributor.author Shah, S.
dc.contributor.author Kohl, T.A.
dc.contributor.author Smith, G.
dc.contributor.author Solano, Walter
dc.contributor.author Spitaleri, A.
dc.contributor.author Supply, P.
dc.contributor.author Steyn, A.J.C.
dc.contributor.author Surve, U.
dc.contributor.author Tahseen, S.
dc.contributor.author Thuong, N.T.T.
dc.contributor.author Thwaites, G.
dc.contributor.author Todt, K.
dc.contributor.author Trovato, A.
dc.contributor.author Utpatel, C.
dc.contributor.author Van Rie, A.
dc.contributor.author Vijay, S.
dc.contributor.author Walker, A.S.
dc.contributor.author Warren, R.
dc.contributor.author Werngren, J.
dc.contributor.author Wijkander, M.
dc.contributor.author Wilkinson, R.J.
dc.contributor.author Wilson, D.J.
dc.contributor.author Wintringer, P.
dc.contributor.author Xiao, Y.-X.
dc.contributor.author Yang, Y.
dc.contributor.author Yanlin, Z.
dc.contributor.author Yao, S.-Y.
dc.contributor.author Zhu, B.
dc.contributor.author The Zooniverse Volunteer Community
dc.contributor.author The CRyPTIC Consortium
dc.date.accessioned 2022-09-09T18:52:22Z
dc.date.available 2022-09-09T18:52:22Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12143
dc.description.abstract Tuberculosis is a respiratory disease that is treatable with antibiotics. An increasing prevalence of resistance means that to ensure a good treatment outcome it is desirable to test the susceptibility of each infection to different antibiotics. Conventionally this is done by culturing a clinical sample and then exposing aliquots to a panel of antibiotics, Using 96-well broth micro dilution plates with each well containing a lyophilised predetermined amount of an antibiotic is a convenient and cost-effective way to measure the MICs of several drugs at once for a clinical sample. Although accurate, this is still an expensive and slow process that requires highlyskilled and experienced laboratory scientists. Here we show that, through the BashTheBug project hosted on the Zooniverse citizen science platform, a crowd of volunteers can reproducibly and accurately determine the MICs for 13 drugs and that simply taking the median or mode of 11-17 independent classifications is sufficient. There is therefore a potential role for crowds to support (but not supplant) the role of experts in antibiotic susceptibility testing. en_US
dc.language.iso eng
dc.publisher eLife Sciences Publications
dc.relation.ispartofseries eLife
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject BashTheBug en_US
dc.subject minimum inhibitory concentrations en_US
dc.subject antitubercular drugs en_US
dc.subject photographs en_US
dc.subject microdilution plates en_US
dc.title A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.7554/eLife.75046
dc.relation.issn 2050-084X


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