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dc.contributor.author | Millones Gomez, Pablo Alejandro | |
dc.contributor.author | Requena Mendizabal, Margarita Fe | |
dc.contributor.author | Calla Poma, Roger Damaso | |
dc.contributor.author | Rosales Cifuentes, Tania Valentina | |
dc.contributor.author | Malpartida Quispe, Federico Martin | |
dc.contributor.author | Maurtua Torres, Dora Jesus | |
dc.contributor.author | Bacilio Amaranto, Reyma Evelyn | |
dc.contributor.author | Minchon Medina, Carlos Alberto | |
dc.contributor.author | Ponce Contreras, Lusin Antonio | |
dc.date.accessioned | 2022-09-09T18:52:22Z | |
dc.date.available | 2022-09-09T18:52:22Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/12144 | |
dc.description.abstract | Objective: To assess the antibacterial activity of Psidium guajava fractions and their effects on adhesion of a multispecies biofilm consisting of Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis in vitro. Material and Methods: Guava leaves were obtained from the mountains of northern Peru, where they grow wild and free of pesticides. The antimicrobial activity of 25 mg/mL petroleum ether, 25 mg/mL dichloromethane and 25 mg/mL methanol fractions of P. guajava was evaluated by measuring inhibition halos, as well as the effect on the adhesion of multispecies biofilms at 4, 7 and 10 days of growth by measuring the optical density. In addition, antimicrobial susceptibility was compared using the Kruskal-Wallis test and its multiple comparison tests, and differences in mean biofilm adhesion between each fraction were assessed by repeated measures analysis and the Tukey multiple comparison test. Results: The rank-based Kruskal-Wallis test highlighted differences in the effects of the fractions on the zone of inhibition for each oral bacterium, including S. gordonii (p=0.000), F. nucleatum (p=0.000), and P. gingivalis (p=0.000), the Tukey test showed that the group treated with 0.12% chlorhexidine exhibited the least amount of adhesion, followed by the group treated with the 1.56 mg/mL methanol fraction. Conclusion: The methanol fraction of P. guajava had an antibacterial effect on S. gordonii and P. gingivalis, and the 1.56 mg/mL methanol fraction decreased biofilm adhesion. | en_US |
dc.language.iso | eng | |
dc.publisher | Association of Support to Oral Health Research | |
dc.relation.ispartofseries | Pesquisa Brasileira em Odontopediatria e Clinica Integrada | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Psidium | en_US |
dc.subject | Biofilms | en_US |
dc.subject | Gram-Negative Bacteria | en_US |
dc.title | Antibacterial and Antiadhesion Effects of Psidium guajava Fractions on a Multispecies Biofilm Associated with Periodontitis | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1590/pboci.2022.028 | |
dc.relation.issn | 1983-4632 |
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