Universidad Peruana Cayetano Heredia

Antibacterial and Antiadhesion Effects of Psidium guajava Fractions on a Multispecies Biofilm Associated with Periodontitis

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dc.contributor.author Millones Gomez, Pablo Alejandro
dc.contributor.author Requena Mendizabal, Margarita Fe
dc.contributor.author Calla Poma, Roger Damaso
dc.contributor.author Rosales Cifuentes, Tania Valentina
dc.contributor.author Malpartida Quispe, Federico Martin
dc.contributor.author Maurtua Torres, Dora Jesus
dc.contributor.author Bacilio Amaranto, Reyma Evelyn
dc.contributor.author Minchon Medina, Carlos Alberto
dc.contributor.author Ponce Contreras, Lusin Antonio
dc.date.accessioned 2022-09-09T18:52:22Z
dc.date.available 2022-09-09T18:52:22Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12144
dc.description.abstract Objective: To assess the antibacterial activity of Psidium guajava fractions and their effects on adhesion of a multispecies biofilm consisting of Streptococcus gordonii, Fusobacterium nucleatum, and Porphyromonas gingivalis in vitro. Material and Methods: Guava leaves were obtained from the mountains of northern Peru, where they grow wild and free of pesticides. The antimicrobial activity of 25 mg/mL petroleum ether, 25 mg/mL dichloromethane and 25 mg/mL methanol fractions of P. guajava was evaluated by measuring inhibition halos, as well as the effect on the adhesion of multispecies biofilms at 4, 7 and 10 days of growth by measuring the optical density. In addition, antimicrobial susceptibility was compared using the Kruskal-Wallis test and its multiple comparison tests, and differences in mean biofilm adhesion between each fraction were assessed by repeated measures analysis and the Tukey multiple comparison test. Results: The rank-based Kruskal-Wallis test highlighted differences in the effects of the fractions on the zone of inhibition for each oral bacterium, including S. gordonii (p=0.000), F. nucleatum (p=0.000), and P. gingivalis (p=0.000), the Tukey test showed that the group treated with 0.12% chlorhexidine exhibited the least amount of adhesion, followed by the group treated with the 1.56 mg/mL methanol fraction. Conclusion: The methanol fraction of P. guajava had an antibacterial effect on S. gordonii and P. gingivalis, and the 1.56 mg/mL methanol fraction decreased biofilm adhesion. en_US
dc.language.iso eng
dc.publisher Association of Support to Oral Health Research
dc.relation.ispartofseries Pesquisa Brasileira em Odontopediatria e Clinica Integrada
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Psidium en_US
dc.subject Biofilms en_US
dc.subject Gram-Negative Bacteria en_US
dc.title Antibacterial and Antiadhesion Effects of Psidium guajava Fractions on a Multispecies Biofilm Associated with Periodontitis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1590/pboci.2022.028
dc.relation.issn 1983-4632


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