Universidad Peruana Cayetano Heredia

Genetic diversity and population structure of Leishmania (Viannia) braziliensis in the Peruvian jungle

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dc.contributor.author De Los Santos, Maxy B.
dc.contributor.author Ramirez, Ivonne Melissa
dc.contributor.author Rodriguez, Jorge E.
dc.contributor.author Beerli, Peter
dc.contributor.author Valdivia, Hugo O.
dc.date.accessioned 2022-09-09T18:52:22Z
dc.date.available 2022-09-09T18:52:22Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12150
dc.description.abstract Background Human cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis is highly prevalent in the Peruvian jungle, where it affects military forces deployed to fight against drug trafficking and civilian people that migrate from the highland to the lowland jungle for economic activities such as mining, agriculture, construction, and chestnut harvest. We explored the genetic diversity and population structure of 124 L. (V.) braziliensis isolates collected from the highland (Junfn, Cusco, and Ayacucho) and lowland Peruvian jungle (Loreto, Ucayali, and Madre de Dios). All samples were genotyped using Multilocus Microsatellite Typing (MLMT) of ten highly polymorphic markers. Principal findings High polymorphism and genetic diversity were found in Peruvian isolates of L. (V.) braziliensis. Most markers are not in Hardy-Weinberg equilibrium; this deviation is most likely caused by local inbreeding, as shown by the positive FS values. Linkage Disequilibrium in subpopulations was not strong, suggesting the reproduction was not strictly clonal. Likewise, for the first time, two genetic clusters of this parasite were determined, distributed in both areas of the Peruvian jungle, which suggested a possible recent colonization event of the highland jungle from the lowland jungle. Conclusions L. (V.) braziliensis exhibits considerable genetic diversity with two different clusters in the Peruvian jungle. Migration analysis suggested a colonization event between geographical areas of distribution. Although no human migration was observed at the time of sampling, earlier displacement of humans, reservoirs, or vectors could have been responsible for the parasite spread in both regions. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Brazil en_US
dc.subject Jungles en_US
dc.subject Population genetics en_US
dc.subject Peru en_US
dc.subject Genetic loci en_US
dc.subject Microsatellite loci en_US
dc.subject Phylogeography en_US
dc.subject Gene flow en_US
dc.title Genetic diversity and population structure of Leishmania (Viannia) braziliensis in the Peruvian jungle en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0010374
dc.relation.issn 1935-2735


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