Universidad Peruana Cayetano Heredia

Increased iron uptake in the bladder wall of racemose cysts of Taenia solium

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dc.contributor.author Orrego Solano, Miguel Ángel
dc.contributor.author Vasquez, Carlos M.
dc.contributor.author Togneri, Kayla
dc.contributor.author Laclette, Juan P.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Nash, Theodore E.
dc.contributor.author Cysticercosis Working Grp Peru
dc.date.accessioned 2022-09-09T18:52:23Z
dc.date.available 2022-09-09T18:52:23Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12156
dc.description.abstract Racemose neurocysticercosis is an aggressive infection caused by the aberrant expansion and proliferation of the bladder wall of the Taenia solium cyst within the subarachnoid spaces of the human brain. The parasite develops and proliferates in a microenvironment with low concentrations of growth factors and micronutrients compared to serum. Iron is important for essential biological processes, but its requirement for racemose cyst viability and proliferation has not been studied. The presence of iron in the bladder wall of racemose and normal univesicular T. solium cysts was determined using Prussian blue staining. Iron deposits were readily detected in the bladder wall of racemose cysts but were not detectable in the bladder wall of univesicular cysts. Consistent with this finding, the genes for two iron-binding proteins (ferritin and melanotransferrin) and ribonucleotide reductase were markedly overexpressed in the racemose cyst compared to univesicular cysts. The presence of iron in the bladder wall of racemose cysts may be due to its increased metabolic rate due to proliferation. en_US
dc.description.sponsorship Este trabajo fue financiado parcialmente por CONCYTEC – Banco Mundial, a través de su unidad ejecutora Contrato Fondo Nacional para el Desarrollo de la Ciencia, la Tecnología y la Innovación Tecnológica (FONDECYT) [E033-01-08- 2018-FONDECYT/Banco Mundial-Programas de Doctorado en Áreas Estratégicas y Generales]. es_PE
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Molecular and Biochemical Parasitology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Taenia solium en_US
dc.subject Neurocysticercosis en_US
dc.subject Cisticercosis en_US
dc.subject Subarachnoid cyst en_US
dc.subject Ferritin en_US
dc.subject Iron metabolism en_US
dc.subject Ribonucleotide reductase en_US
dc.title Increased iron uptake in the bladder wall of racemose cysts of Taenia solium en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.molbiopara.2022.111496
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 1872-9428


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