Increased iron uptake in the bladder wall of racemose cysts of Taenia solium

Nash, Theodore E.; García Lescano, Héctor Hugo; Vasquez, Carlos M.; Orrego Solano, Miguel Ángel; Laclette, Juan P.; Togneri, Kayla; Cysticercosis Working Grp Peru

dc.contributor.author	Orrego Solano, Miguel Ángel
dc.contributor.author	Vasquez, Carlos M.
dc.contributor.author	Togneri, Kayla
dc.contributor.author	Laclette, Juan P.
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Nash, Theodore E.
dc.contributor.author	Cysticercosis Working Grp Peru
dc.date.accessioned	2022-09-09T18:52:23Z
dc.date.available	2022-09-09T18:52:23Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12156
dc.description.abstract	Racemose neurocysticercosis is an aggressive infection caused by the aberrant expansion and proliferation of the bladder wall of the Taenia solium cyst within the subarachnoid spaces of the human brain. The parasite develops and proliferates in a microenvironment with low concentrations of growth factors and micronutrients compared to serum. Iron is important for essential biological processes, but its requirement for racemose cyst viability and proliferation has not been studied. The presence of iron in the bladder wall of racemose and normal univesicular T. solium cysts was determined using Prussian blue staining. Iron deposits were readily detected in the bladder wall of racemose cysts but were not detectable in the bladder wall of univesicular cysts. Consistent with this finding, the genes for two iron-binding proteins (ferritin and melanotransferrin) and ribonucleotide reductase were markedly overexpressed in the racemose cyst compared to univesicular cysts. The presence of iron in the bladder wall of racemose cysts may be due to its increased metabolic rate due to proliferation.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Molecular and Biochemical Parasitology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Taenia solium	en_US
dc.subject	Neurocysticercosis	en_US
dc.subject	Cisticercosis	en_US
dc.subject	Subarachnoid cyst	en_US
dc.subject	Ferritin	en_US
dc.subject	Iron metabolism	en_US
dc.subject	Ribonucleotide reductase	en_US
dc.title	Increased iron uptake in the bladder wall of racemose cysts of Taenia solium	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/j.molbiopara.2022.111496
dc.relation.issn	1872-9428