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Plasmids in Salmonella typhi in Lima, Peru, 1987-1988: epidemiology and lack of association with severity of illness or clinical complications

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dc.contributor.author Finch, M. J.
dc.contributor.author Franco, A.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Carrillo, Carlos
dc.contributor.author Benavente, L.
dc.contributor.author Wasserman, S. S.
dc.contributor.author Levine, M. M.
dc.contributor.author Morris, J. G.
dc.date.accessioned 2022-10-09T15:38:47Z
dc.date.available 2022-10-09T15:38:47Z
dc.date.issued 1992
dc.identifier.uri https://hdl.handle.net/20.500.12866/12270
dc.description.abstract A prospective study was conducted to better characterize the epidemiology of plasmid-bearing strains of Salmonella typhi in an endemic area of Lima, Peru, and to determine if plasmids were associated with specific manifestations of typhoid fever. Of 228 S. typhi isolated from patients at Cayetano Heredia University Hospital in Lima during 1987-1988, 76 (33%) contained plasmids. Ten different plasmid profiles were identified, with ten distinct plasmids present within these profiles. There was significant temporal clustering of isolates having common plasmid profiles. Two plasmids (both from the same isolate) carried antibiotic resistance genes. Two cryptic plasmids with approximate sizes of 55 and 65 kilobases (kb) appeared to be closely related, based on restriction endonuclease digestions and Southern blot analysis. An ampicillin resistance plasmid from a 1989 patient isolate differed by only a single restriction fragment from the cryptic 65-kb plasmid. No association was found between any plasmid or plasmid profile and severity or clinical manifestations of disease. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Plasmids en_US
dc.subject Cluster Analysis en_US
dc.subject Humans en_US
dc.subject Salmonella typhi en_US
dc.subject pathogenicity en_US
dc.subject epidemiology en_US
dc.title Plasmids in Salmonella typhi in Lima, Peru, 1987-1988: epidemiology and lack of association with severity of illness or clinical complications en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.1992.47.390
dc.relation.issn 1476-1645


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