Plasmids in Salmonella typhi in Lima, Peru, 1987-1988: epidemiology and lack of association with severity of illness or clinical complications

Franco, A.; Morris, J. G.; Benavente, L.; Levine, M. M.; Wasserman, S. S.; Gotuzzo Herencia, José Eduardo; Carrillo, Carlos; Finch, M. J.

dc.contributor.author	Finch, M. J.
dc.contributor.author	Franco, A.
dc.contributor.author	Gotuzzo Herencia, José Eduardo
dc.contributor.author	Carrillo, Carlos
dc.contributor.author	Benavente, L.
dc.contributor.author	Wasserman, S. S.
dc.contributor.author	Levine, M. M.
dc.contributor.author	Morris, J. G.
dc.date.accessioned	2022-10-09T15:38:47Z
dc.date.available	2022-10-09T15:38:47Z
dc.date.issued	1992
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12270
dc.description.abstract	A prospective study was conducted to better characterize the epidemiology of plasmid-bearing strains of Salmonella typhi in an endemic area of Lima, Peru, and to determine if plasmids were associated with specific manifestations of typhoid fever. Of 228 S. typhi isolated from patients at Cayetano Heredia University Hospital in Lima during 1987-1988, 76 (33%) contained plasmids. Ten different plasmid profiles were identified, with ten distinct plasmids present within these profiles. There was significant temporal clustering of isolates having common plasmid profiles. Two plasmids (both from the same isolate) carried antibiotic resistance genes. Two cryptic plasmids with approximate sizes of 55 and 65 kilobases (kb) appeared to be closely related, based on restriction endonuclease digestions and Southern blot analysis. An ampicillin resistance plasmid from a 1989 patient isolate differed by only a single restriction fragment from the cryptic 65-kb plasmid. No association was found between any plasmid or plasmid profile and severity or clinical manifestations of disease.	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Plasmids	en_US
dc.subject	Cluster Analysis	en_US
dc.subject	Humans	en_US
dc.subject	Salmonella typhi	en_US
dc.subject	pathogenicity	en_US
dc.subject	epidemiology	en_US
dc.title	Plasmids in Salmonella typhi in Lima, Peru, 1987-1988: epidemiology and lack of association with severity of illness or clinical complications	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.1992.47.390
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645