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An evaluation of diagnostic methods for brucellosis—the value of bone marrow culture

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dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Carrillo, Carlos P.
dc.contributor.author Guerra, Jorge G.
dc.contributor.author Llosa Isenrich, Maria Paola Lucia
dc.date.accessioned 2022-10-09T16:39:03Z
dc.date.available 2022-10-09T16:39:03Z
dc.date.issued 1986
dc.identifier.uri https://hdl.handle.net/20.500.12866/12271
dc.description.abstract Fifty patients, eventually diagnosed as having brucellosis, were studied prospectively for comparison of a simple culture of bone marrow aspirate from the iliac crest (0.5–1.0 ml) with two cultures of blood (5–10 ml) taken 30–60 min apart and with a tube-agglutination test. Cultures of bone marrow and blood were positive in 92% and 70 070 of the patients, respectively (P <.001). Bacteria multiplied significantly faster in bone marrow cultures (4.32 vs. 6.65 days; P <001). All isolates were identified as Brucella melitensis biotype 1. Serological diagnosis was established in 86% of the patients. The efficacy of cultures of blood decreased significantly with chronic and subacute forms of infection, whereas that of bone marrow culture decreased only in chronic forms. Prior use of antibiotics reduced the positivity of cultures of blood but did not affect bone marrow culture. Bone marrow culture is recommended for patients with fever of unknown origin, negative serology, and unexplained articular or hematologic involvement, and patients in whom brucellosis is suspected. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject bacterium culture en_US
dc.subject blood and hemopoietic system en_US
dc.subject bone marrow culture en_US
dc.subject brucella melitensis en_US
dc.subject brucellosis en_US
dc.subject diagnosis en_US
dc.subject human en_US
dc.subject methodology en_US
dc.subject serology en_US
dc.subject Agglutination Tests en_US
dc.subject Brucella en_US
dc.title An evaluation of diagnostic methods for brucellosis—the value of bone marrow culture en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/153.1.122
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.00
dc.type.version info:eu-repo/semantics/publishedVersion
dc.relation.issn 1537-6613


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