Universidad Peruana Cayetano Heredia

Lutzomyia verrucarum can transmit Leishmania peruviana, the aetiological agent of Andean cutaneous leishmaniasis

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dc.contributor.author Davies, C.R.
dc.contributor.author Roncal, N.
dc.contributor.author Paz, Lourdes
dc.contributor.author Fernandez, Martha
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.date.accessioned 2022-10-09T17:42:33Z
dc.date.available 2022-10-09T17:42:33Z
dc.date.issued 1993
dc.identifier.uri https://hdl.handle.net/20.500.12866/12278
dc.description.abstract In much of the endemic area for cutaneous leishmaniasis (uta) in the Peruvian Andes, the only 2 anthropophilic sandfly species present are Lutzomyia peruensis and Lu. verrucarum. On the basis of a single confirmed isolation of Leishmania peruviana (the aetiological agent of uta) from a wild Lu. peruensis, and apparent associations between sandfly abundance and the incidence of uta, it is generally believed that Lu. peruensis is the most important vector. In this paper, a potential role for Lu. verrucarum in the transmission of uta is indicated by laboratory experiments which show that this species is vectorially competent for L. peruviana. Individual or pooled colonized sandflies were permitted to take a second blood meal on 22 susceptible golden hamsters at varying intervals after feeding on hamsters previously infected with L. peruviana. Transmission was achieved by a single infected sandfly (of a total of 59) following a 15 d incubation period. Transmission was recognized by the characteristic clinical response (footpad swelling) associated with hamsters which have been inoculated with L. peruviana, and by the presence of parasites in aspirates made from the swollen footpad, detected by the polymerase chain reaction (PCR) and by parasite isolations in biphasic blood-agar culture medium. The identity of the parasite isolates was also confirmed by PCR (specific for parasites in the L. braziliensis complex). This is the first reported experimental transmission of L. peruviana by any sandfly species. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Transactions of the Royal Society of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Lutzomyia verrucarum en_US
dc.subject Psychodidae en_US
dc.subject Animal en_US
dc.subject Animalia en_US
dc.subject Insect Vectors en_US
dc.subject Leishmania braziliensis en_US
dc.subject Leishmaniasis, Cutaneous en_US
dc.subject parasite transmission en_US
dc.subject parasite vector en_US
dc.subject Phlebotominae en_US
dc.subject polymerase chain reaction en_US
dc.subject psychodidae en_US
dc.subject Support, Non-U.S. Gov't en_US
dc.subject Uta en_US
dc.subject controlled study en_US
dc.subject skin leishmaniasis en_US
dc.subject Time Factors en_US
dc.subject animal model en_US
dc.subject Cricetinae en_US
dc.subject culture medium en_US
dc.subject endemic disease en_US
dc.subject feeding en_US
dc.subject foot pad en_US
dc.subject Hamsters en_US
dc.subject incubation time en_US
dc.subject Leishmania peruviana en_US
dc.subject Lutzomyia peruensis en_US
dc.subject Mesocricetus auratus en_US
dc.subject parasite isolation en_US
dc.title Lutzomyia verrucarum can transmit Leishmania peruviana, the aetiological agent of Andean cutaneous leishmaniasis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/0035-9203(93)90103-W
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1878-3503


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