Universidad Peruana Cayetano Heredia

Randomized comparison of aztreonam and chloramphenicol in treatment of typhoid fever

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dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Echevarria Zarate, Juan Ignacio
dc.contributor.author Carrillo, Carlos
dc.contributor.author Sánchez, J.
dc.contributor.author Grados, P.
dc.contributor.author Maguiña Vargas, Ciro
dc.contributor.author DuPont, H. L.
dc.date.accessioned 2022-10-09T17:42:33Z
dc.date.available 2022-10-09T17:42:33Z
dc.date.issued 1994
dc.identifier.uri https://hdl.handle.net/20.500.12866/12280
dc.description.abstract Patients with clinical typhoid fever plus a blood, bone marrow, or bile culture positive for Salmonella typhi or Salmonella paratyphi mere included in an open clinical trial to compare the efficacy of aztreonam (6 g/day [2 g intravenously every 8 h]) given for 10 days with that of chloramphenicol (50 mg/kg of body weight per day [intravenously or orally]) administered for 14 days. A total of 44 patients, 22 in each group, were included in the study, and both groups were comparable in terms of baseline parameters. All patients randomized to receive chloramphenicol completed the 14 days of treatment, while two patients randomized to receive aztreonam developed an intestinal hemorrhage, and a third patient elected to withdraw from the trial. Defervescence occurred more quickly in the subjects receiving chloramphenicol than in those receiving aztreonam (P < 0.05). All patients in the chloramphenicol group were clinically cured during therapy, while four patients (21%) in the group receiving aztreonam were declared clinical treatment failures. None of the 19 patients receiving aztreonam, compared with 7 of 22 (32%) patients receiving chloramphenicol, had a positive blood culture after 24 h of therapy (P < 0.05). Adverse experiences were unusual and mild. In the study, aztreonam was less effective than chloramphenicol with regard to clinical effectiveness and time of defervescence but was more effective in the elimination of the infecting Salmonella organisms from the bloodstream. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Antimicrobial Agents and Chemotherapy
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Aztreonam/adverse effects/therapeutic use en_US
dc.subject Chloramphenicol/adverse effects/therapeutic use en_US
dc.subject Double-Blind Method en_US
dc.subject Feces/microbiology en_US
dc.subject Paratyphoid Fever/blood/drug therapy/microbiology en_US
dc.subject Salmonella paratyphi A en_US
dc.subject Salmonella typhi en_US
dc.subject Typhoid Fever/blood/*drug therapy/microbiology en_US
dc.title Randomized comparison of aztreonam and chloramphenicol in treatment of typhoid fever en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/AAC.38.3.558
dc.relation.issn 1098-6596


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