Universidad Peruana Cayetano Heredia

Characterization of Leishmania species from Peru

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dc.contributor.author Romero, G.G.
dc.contributor.author Arana, Margarita
dc.contributor.author López, Martin
dc.contributor.author Montoya, I.
dc.contributor.author Bohl, R.
dc.contributor.author Campos Sanchez, Miguel
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.date.accessioned 2022-10-09T21:43:21Z
dc.date.available 2022-10-09T21:43:21Z
dc.date.issued 1987
dc.identifier.uri https://hdl.handle.net/20.500.12866/12292
dc.description.abstract Twenty-six isolates of Leishmania parasites of Peruvian origin were studied by isoenzyme electrophoresis of four marker enzymes (ASAT, ALAT, G6PD and GPI), kinetoplast DNA hybridization and monoclonal antibody binding and compared with marker strains of the New World organisms L. b. braziliensis, L. b. guyanensis, L. m. mexicana and L. m. amazonensis. 12 of the isolates studied were of Andean origin; 11 of these were isolated from patients with Andean cutaneous leishmaniasis. The organisms originating from the Peruvian Amazonian forest were isolated from patients with cutaneous (12 cases) or mucocutaneous (2 cases) leishmaniasis. One of the Andean isolates was obtained from an infected phlebotomine vector. 25 of the new isolates were identified as L. braziliensis ssp. according to the three techniques employed. The results of monoclonal antibody binding showed that 23 of the isolates were indistinguishable from L. b. braziliensis. Two isolates identified as L. braziliensis ssp. according to their isoenzyme profiles and k-DNA hybridization patterns could not be classified at the subspecies level. The isolate obtained from the phlebotomine vector could not be identified. No evidence of the existence of parasites of the L. mexicana complex in Peruvian territory was found in this study. The results obtained show a remarkable similarity between Leishmania of Andean origin and L. b. braziliensis. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Transactions of the Royal Society of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject cutaneous leishmaniasis en_US
dc.subject monoclonal antibodiesdna en_US
dc.subject dna en_US
dc.subject kinetoplast en_US
dc.subject electrophoresis en_US
dc.subject glucosephosphate dehydrogenase en_US
dc.subject isoenzymes en_US
dc.subject leishmania en_US
dc.subject leishmaniasis en_US
dc.subject parasites en_US
dc.subject peru en_US
dc.subject enzymes en_US
dc.subject abcb7 gene en_US
dc.title Characterization of Leishmania species from Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/0035-9203(87)90270-7
dc.relation.issn 1878-3503


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