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Association between specific plasmids and relapse in typhoid fever

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dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Morris Jr., J. Glenn
dc.contributor.author Benavente, L.
dc.contributor.author Wood, Patrick K.
dc.contributor.author Levine, Orin
dc.contributor.author Black, Robert E.
dc.contributor.author Levine, Myron M.
dc.date.accessioned 2022-10-09T21:43:21Z
dc.date.available 2022-10-09T21:43:21Z
dc.date.issued 1987
dc.identifier.uri https://hdl.handle.net/20.500.12866/12293
dc.description.abstract We studied isolates from 73 patients hospitalized with typhoid fever in Lima, Peru. Of these 73 patients, 11 (15%) suffered a clinical relapse, with fever and positive blood cultures, within 3 months of their original illness. Using plasmids as epidemiologic markers, we found that three patients who subsequently relapsed were initially infected with more than one strain of Salmonella typhi. There was a highly significant association between relapse and isolation of a strain containing either a 24- or 38-kilobase plasmid at the time of the original infection; however, we were unable to show any evidence of homology between these two plasmids. Our data indicate that infection with multiple strains is not uncommon in this endemic area and suggest that relapse may be partly strain dependent. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartofseries Journal of Clinical Microbiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Specific Plasmids en_US
dc.subject Typhoid Fever en_US
dc.subject Association en_US
dc.title Association between specific plasmids and relapse in typhoid fever en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/jcm.25.9.1779-1781.1987
dc.relation.issn 1098-660X


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