Universidad Peruana Cayetano Heredia

Comparison of chromosome and isoenzyme polymorphism in geographical populations of Leishmania (Viannia) peruviana

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dc.contributor.author Dujardin, J.C.
dc.contributor.author Bañuls, A.L.
dc.contributor.author Dujardin, J.P.
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Tibayrenc, M.
dc.contributor.author Le Ray, D.
dc.date.accessioned 2022-10-09T22:16:52Z
dc.date.available 2022-10-09T22:16:52Z
dc.date.issued 1998
dc.identifier.uri https://hdl.handle.net/20.500.12866/12295
dc.description.abstract Five chromosomes and 17 isoenzyme loci were analysed in 4 allopatric populations of Leishmania (Viannia) peruviana, and molecular distances calculated with 2 estimators, Chromosomal Size Difference Index and Jaccard Distance. Chromosome and isoenzyme data were in overall concordance: 13/30 isolates clustered similarly on the dendrograms constructed from the different estimators, and a significant correlation (P < 0.001)was observed between the molecular distances calculated from the two sets of characters. This indicates an evolutionary association between chromosomal size polymorphism and isoenzymes. Chromosomes have a faster molecular clock than isoenzymes twice as many genotypes were identified by chromosome analysis and significant size differences (for a total of up to 500 kb for 5 chromosomes together) were observed within a given zymodeme. Chromosomes most likely represent better indicators of genetic drift than isoenzymes, as suggested by the higher correlation between both estimators of chromosomal size-polymorphism and eco-geography. Some chromosomes might present an adaptive response to environmental variation. en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartofseries Parasitology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Drift en_US
dc.subject Isoenzymes en_US
dc.subject Karyotype en_US
dc.subject Leishmania (Viannia) peruviana en_US
dc.subject Selection en_US
dc.title Comparison of chromosome and isoenzyme polymorphism in geographical populations of Leishmania (Viannia) peruviana en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/S0031182098003357
dc.relation.issn 1469-8161


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