Universidad Peruana Cayetano Heredia

Recombinant antigens for specific and sensitive serodiagnosis of Latin American tegumentary leishmaniasis

Mostrar el registro sencillo del ítem

dc.contributor.author Montoya, Y.
dc.contributor.author Leon, C.
dc.contributor.author Talledo Albujar, Michael John
dc.contributor.author Nolasco, O.
dc.contributor.author Padilla, C.
dc.contributor.author Muñoz-Najar, U.
dc.contributor.author Barker, D.C.
dc.date.accessioned 2022-10-09T22:16:52Z
dc.date.available 2022-10-09T22:16:52Z
dc.date.issued 1997
dc.identifier.uri https://hdl.handle.net/20.500.12866/12302
dc.description.abstract The diagnostic potential of recombinant leishmanial antigens for Latin American tegumentary leishmaniasis (LATL) was examined. Two Leishmania (Viannia) peruviana recombinant proteins, T26-U2 and T26-U4, were assessed by their reactivity to detect specific anti-leishmanial antibodies. Seventy-eight individual sera from persons with LATL, 39 from those with other diseases, and 10 negative control sera were tested by Western blotting and enzyme-linked immunosorbent assay. The sensitivity of the test using T26-U2 plus T26-U4 was similar to that obtained with whole parasite extract (92%). However, the specificity obtained using both recombinant antigens (87%) was higher than that of the whole parasite extract (65%). All tests using recombinant proteins (T26-U2, T26-U2 plus T26-U4 or T26-U4:) had a higher positive predictive value (89%, 92% and 98%, respectively) than the value obtained using total parasites (81%). Eleven Colombian sera were also tested, and the results indicated that T26-U2 plus T26-U4 could be used successfully in Peru and in other Latin American countries. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Transactions of the Royal Society of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Diagnosis en_US
dc.subject Leishmania peruviana en_US
dc.subject Leishmaniasis en_US
dc.subject Recombinant proteins en_US
dc.title Recombinant antigens for specific and sensitive serodiagnosis of Latin American tegumentary leishmaniasis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/S0035-9203(97)90520-4
dc.relation.issn 1878-3503


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas