Universidad Peruana Cayetano Heredia

Measles Encephalomyelitis - Clinical and Immunologic Studies

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dc.contributor.author Johnson, R.T.
dc.contributor.author Griffin, D.E.
dc.contributor.author Hirsch, R.L.
dc.contributor.author Wounsky, J.S.
dc.contributor.author Roedenbeck, S.
dc.contributor.author de Soriano, Imelda Lindo
dc.contributor.author Vaisberg Wollach, Abraham Jaime
dc.date.accessioned 2022-10-09T23:25:32Z
dc.date.available 2022-10-09T23:25:32Z
dc.date.issued 1984
dc.identifier.uri https://hdl.handle.net/20.500.12866/12311
dc.description.abstract We studied 19 patients with postinfectious encephalomyelitis complicating natural measles-virus infections, and our results support the hypothesis that this demyelinating disease has a pathogenesis similar to that of experimental allergic encephalomyelitis. Early myelin destruction was demonstrated by the presence of myelin basic protein in cerebrospinal fluid, and lymphocyte proliferative responses to myelin basic protein were found in 8 of 17 patients tested. A lack of intrathecal synthesis of antibody against measles virus suggests that measles encephalomyelitis may not be dependent on virus replication within the central nervous system. Similar lymphoproliferative responses to myelin basic protein of lymphocytes from single patients with encephalomyelitis after rabies vaccine or after varicella or rubella virus infections suggest a common immune-mediated pathogenesis for the perivenular demyelinating disease that can follow the injection of neural tissues or infection by a variety of viruses. en_US
dc.language.iso eng
dc.publisher Massachusetts Medical Society
dc.relation.ispartofseries New England Journal of Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Measles Encephalomyelitis en_US
dc.subject Clinical and Immunologic Studies en_US
dc.title Measles Encephalomyelitis - Clinical and Immunologic Studies en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1056/NEJM198401193100301
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1533-4406


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