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dc.contributor.author Crosby, E.
dc.contributor.author Llosa, L.
dc.contributor.author Quesada, M.M.
dc.contributor.author Carrillo, P.C.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2022-10-09T23:25:32Z
dc.date.available 2022-10-09T23:25:32Z
dc.date.issued 1984
dc.identifier.uri https://hdl.handle.net/20.500.12866/12312
dc.description.abstract Hematologic abnormalities were studied prospectively in 38 patients with brucellosis. Anemia was found in 74% of patients, leukopenia in 45%, neutropenia in 21%, lymphopenia in 63% and thrombocytopenia in 39.5%. Eight patients (21%) were pancytopenic|; seven of these individuals also had splenomegaly. Bone marrow hypoplasia was not found. Bleeding complications developed in 26% of patients and were significantly associated with clotting abnormalities (low platelet count, low fibrinogen level, and/or prolongation of thrombin clotting time); i.e., bleeding occurred in ~50% of patients with marked clotting abnormalities but in no patients with normal clotting. Determination of fibrinogen levels at different stages of brucellosis led to a redefinition of the normal level for patients with this infection. Patients without clotting abnormalities had fibrinogen levels of 233-711 mg/100 ml (mean, 384 mg/100 ml), whereas patients with thrombocytopenia and prolonged thrombin clotting time had levels of 122-360 mg/100 ml (mean, 216 mg/100 ml; P < .001) that increased to 233-519 mg/100 (mean, 360 mg/100 ml) when clotting values returned to normal. Lymphopenia was significantly correlated with the severity of clinical manifestations (bleeding and hepatic involvement). en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject anemia en_US
dc.subject hemorrhage en_US
dc.subject brucellosis en_US
dc.subject neutropenia en_US
dc.subject blood coagulation en_US
dc.subject leukopenia en_US
dc.subject lymphopenia en_US
dc.subject splenomegaly en_US
dc.subject thrombin time en_US
dc.subject thrombocytopenia en_US
dc.subject infectionsfibrinogen assay en_US
dc.subject hematology en_US
dc.subject abnormal hematology findings en_US
dc.subject coagulation process en_US
dc.subject bone marrow en_US
dc.subject hypocellular en_US
dc.title Hematologic changes in brucellosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/infdis/150.3.419
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6613


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