Hematologic changes in brucellosis

Quesada, M.M.; Crosby, E.; Llosa, L.; Gotuzzo Herencia, José Eduardo; Carrillo, P.C.

dc.contributor.author	Crosby, E.
dc.contributor.author	Llosa, L.
dc.contributor.author	Quesada, M.M.
dc.contributor.author	Carrillo, P.C.
dc.contributor.author	Gotuzzo Herencia, José Eduardo
dc.date.accessioned	2022-10-09T23:25:32Z
dc.date.available	2022-10-09T23:25:32Z
dc.date.issued	1984
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12312
dc.description.abstract	Hematologic abnormalities were studied prospectively in 38 patients with brucellosis. Anemia was found in 74% of patients, leukopenia in 45%, neutropenia in 21%, lymphopenia in 63% and thrombocytopenia in 39.5%. Eight patients (21%) were pancytopenic\|; seven of these individuals also had splenomegaly. Bone marrow hypoplasia was not found. Bleeding complications developed in 26% of patients and were significantly associated with clotting abnormalities (low platelet count, low fibrinogen level, and/or prolongation of thrombin clotting time); i.e., bleeding occurred in ~50% of patients with marked clotting abnormalities but in no patients with normal clotting. Determination of fibrinogen levels at different stages of brucellosis led to a redefinition of the normal level for patients with this infection. Patients without clotting abnormalities had fibrinogen levels of 233-711 mg/100 ml (mean, 384 mg/100 ml), whereas patients with thrombocytopenia and prolonged thrombin clotting time had levels of 122-360 mg/100 ml (mean, 216 mg/100 ml; P < .001) that increased to 233-519 mg/100 (mean, 360 mg/100 ml) when clotting values returned to normal. Lymphopenia was significantly correlated with the severity of clinical manifestations (bleeding and hepatic involvement).	en_US
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation.ispartofseries	Journal of Infectious Diseases
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	anemia	en_US
dc.subject	hemorrhage	en_US
dc.subject	brucellosis	en_US
dc.subject	neutropenia	en_US
dc.subject	blood coagulation	en_US
dc.subject	leukopenia	en_US
dc.subject	lymphopenia	en_US
dc.subject	splenomegaly	en_US
dc.subject	thrombin time	en_US
dc.subject	thrombocytopenia	en_US
dc.subject	infectionsfibrinogen assay	en_US
dc.subject	hematology	en_US
dc.subject	abnormal hematology findings	en_US
dc.subject	coagulation process	en_US
dc.subject	bone marrow	en_US
dc.subject	hypocellular	en_US
dc.title	Hematologic changes in brucellosis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1093/infdis/150.3.419
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn	1537-6613