Universidad Peruana Cayetano Heredia

Efficacy and tolerability of ciprofloxacin prophylaxis in adult household contacts of patients with cholera

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dc.contributor.author Echevarria Zarate, Juan Ignacio
dc.contributor.author Seas Ramos, Carlos Rafael
dc.contributor.author Carrillo, Carlos
dc.contributor.author Mostorino, Rosa
dc.contributor.author Ruiz, Rosa
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.date.accessioned 2022-10-10T00:48:55Z
dc.date.available 2022-10-10T00:48:55Z
dc.date.issued 1995
dc.identifier.uri https://hdl.handle.net/20.500.12866/12328
dc.description.abstract We conducted a randomized double-blinded study in Lima, Peru, to assess the tolerability and efficacy of a single 250-mg dose of ciprofloxacin in preventing diarrhea and Vibrio cholerae O1 infection among household contacts of bacteriologically confirmed index cases. Adult household contacts with negative baseline stool cultures were included. A total of 213 household contacts were evaluable. The study drugs were well tolerated in both groups. Ciprofloxacin did not prevent the acquisition of V. cholerae O1 infection nor the development of diarrhea. However, in a subgroup of 30 household contacts with positive baseline stool cultures a reduction in the bacterial load and a trend toward prevention of diarrhea were observed among ciprofloxacin recipients. When all household contacts were evaluated, a trend toward prevention of diarrhea was observed with the prophylactic regimen. Ciprofloxacin failed to prevent V. cholerae O1 infections during a period of low transmissibility. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject cholera en_US
dc.subject ciprofloxacin en_US
dc.subject diarrhea en_US
dc.subject adult en_US
dc.subject peru en_US
dc.subject infections en_US
dc.subject stool culture en_US
dc.subject prevention en_US
dc.subject vibrio cholerae en_US
dc.title Efficacy and tolerability of ciprofloxacin prophylaxis in adult household contacts of patients with cholera en_US
dc.title.alternative Eficacia y tolerabilidad de la profilaxis de ciprofloxacina en contactos domésticos adultos de pacientes con cólera es_PE
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/clinids/20.6.1480
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6591


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