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Ciprofloxacin for the treatment of cholera: A randomized, double-blind, controlled clinical trial of a single daily dose in peruvian adults

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dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Seas Ramos, Carlos Rafael
dc.contributor.author Echevarria Zarate, Juan Ignacio
dc.contributor.author Carrillo, Carlos
dc.contributor.author Mostorino, Rosa
dc.contributor.author Ruiz, Rosa
dc.date.accessioned 2022-10-10T00:48:55Z
dc.date.available 2022-10-10T00:48:55Z
dc.date.issued 1995
dc.identifier.uri https://hdl.handle.net/20.500.12866/12331
dc.description.abstract We conducted a randomized, double-blind clinical trial to compare ciprofloxacin (250 mg once a day for 3 days) with tetracycline (500 mg four times a day for 3 days) in terms of efficacy and safety in the treatment of moderate-to-severe cholera in Peruvian adults. The baseline characteristics of the groups were similar. A total of 202 patients (102 in the tetracycline group and 100 in the ciprofloxacin group) were included in the efficacy analysis. The clinical and bacteriologic efficacies of the two regimens were similar. The study drugs were well tolerated. We conclude that ciprofloxacin given once a day is as effective as the standard tetracycline regimen for the treatment of cholera in adults. The ciprofloxacin regimen may represent an alternative to the standard treatment in areas where Vibrio cholerae O1 strains that are resistant to commonly used antimicrobials are prevalent. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Administration en_US
dc.subject Oral en_US
dc.subject Cholera en_US
dc.subject Ciprofloxacin en_US
dc.subject Double-Blind Method en_US
dc.subject Drug Administration Schedule en_US
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Tetracycline en_US
dc.subject Treatment Outcome en_US
dc.title Ciprofloxacin for the treatment of cholera: A randomized, double-blind, controlled clinical trial of a single daily dose in peruvian adults en_US
dc.title.alternative Ciprofloxacina para el tratamiento del cólera: un ensayo clínico aleatorizado, doble ciego, controlado de una sola dosis diaria en adultos peruanos es_PE
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1093/clinids/20.6.1485
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1537-6591


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