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Cutaneous leishmaniasis in the Peruvian Andes: An epidemiological study of infection and immunity

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dc.contributor.author Davies, Clive Richard
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Pyke, Stephen D.M.
dc.contributor.author Dye, Christopher M.
dc.date.accessioned 2022-10-10T00:48:55Z
dc.date.available 2022-10-10T00:48:55Z
dc.date.issued 1995
dc.identifier.uri https://hdl.handle.net/20.500.12866/12333
dc.description.abstract A prospective longitudinal survey of cutaneous leishmaniasis (Leishmania peruviana) was carried out in Peru on a study population of 4716 persons living in 38 villages (Departments of Lima, Ancash and Piura). Demographic and clinical data were collected from all individuals, and a Montenegro skin test (MST) was carried out on 72% (3418) of the study population. Each household was revisited at 3-monthly intervals for up to 2 years to detect new leishmaniasis cases; 497 people received a second MST at the end of the study. Analysis of the epidemiological data indicated that (i) 17% (16/94) of all infections were subclinical, (ii) this percentage increased significantly with age, (iii) clinical infections led to 73·9 % protective immunity (95 % C.I. 53·0–85·5 %) and relatively permanent MST responsiveness (recovery rate = 0·0098/year; 95% C.I. 0·000–0·020/year), (iv) sub-clinical infections led to protective immunity, which was positively correlated with their MST induration size (increasing by 17·9% per mm; P < 0·0001), and a mean MST recovery rate of 0·114/year (4/421 man-months), and (v) recurrent leishmaniasis was dominated by reactivations, not by reinfections. en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartofseries Epidemiology and Infection
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Age Distribution en_US
dc.subject Animal en_US
dc.subject Antigens en_US
dc.subject Protozoan en_US
dc.subject Cross-Sectional Studies en_US
dc.subject Human en_US
dc.subject Immunity, Active en_US
dc.subject Incidence en_US
dc.subject Leishmania braziliensis en_US
dc.subject Leishmaniasis, Cutaneous en_US
dc.subject Peru en_US
dc.subject Prevalence en_US
dc.subject Prospective Studies en_US
dc.subject Recurrence en_US
dc.subject Skin Tests en_US
dc.subject Support, Non-U.S. Gov't en_US
dc.title Cutaneous leishmaniasis in the Peruvian Andes: An epidemiological study of infection and immunity en_US
dc.title.alternative Leishmaniasis cutánea en los Andes peruanos: un estudio epidemiológico de infección e inmunidad es_PE
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/S0950268800057964
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1469-4409


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