Universidad Peruana Cayetano Heredia
Cutaneous leishmaniasis in the Peruvian Andes: An epidemiological study of infection and immunity
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| dc.contributor.author | Davies, Clive Richard | |
| dc.contributor.author | Llanos Cuentas, Elmer Alejandro | |
| dc.contributor.author | Pyke, Stephen D.M. | |
| dc.contributor.author | Dye, Christopher M. | |
| dc.date.accessioned | 2022-10-10T00:48:55Z | |
| dc.date.available | 2022-10-10T00:48:55Z | |
| dc.date.issued | 1995 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/12333 | |
| dc.description.abstract | A prospective longitudinal survey of cutaneous leishmaniasis (Leishmania peruviana) was carried out in Peru on a study population of 4716 persons living in 38 villages (Departments of Lima, Ancash and Piura). Demographic and clinical data were collected from all individuals, and a Montenegro skin test (MST) was carried out on 72% (3418) of the study population. Each household was revisited at 3-monthly intervals for up to 2 years to detect new leishmaniasis cases; 497 people received a second MST at the end of the study. Analysis of the epidemiological data indicated that (i) 17% (16/94) of all infections were subclinical, (ii) this percentage increased significantly with age, (iii) clinical infections led to 73·9 % protective immunity (95 % C.I. 53·0–85·5 %) and relatively permanent MST responsiveness (recovery rate = 0·0098/year; 95% C.I. 0·000–0·020/year), (iv) sub-clinical infections led to protective immunity, which was positively correlated with their MST induration size (increasing by 17·9% per mm; P < 0·0001), and a mean MST recovery rate of 0·114/year (4/421 man-months), and (v) recurrent leishmaniasis was dominated by reactivations, not by reinfections. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Cambridge University Press | |
| dc.relation.ispartofseries | Epidemiology and Infection | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Age Distribution | en_US |
| dc.subject | Animal | en_US |
| dc.subject | Antigens | en_US |
| dc.subject | Protozoan | en_US |
| dc.subject | Cross-Sectional Studies | en_US |
| dc.subject | Human | en_US |
| dc.subject | Immunity, Active | en_US |
| dc.subject | Incidence | en_US |
| dc.subject | Leishmania braziliensis | en_US |
| dc.subject | Leishmaniasis, Cutaneous | en_US |
| dc.subject | Peru | en_US |
| dc.subject | Prevalence | en_US |
| dc.subject | Prospective Studies | en_US |
| dc.subject | Recurrence | en_US |
| dc.subject | Skin Tests | en_US |
| dc.subject | Support, Non-U.S. Gov't | en_US |
| dc.title | Cutaneous leishmaniasis in the Peruvian Andes: An epidemiological study of infection and immunity | en_US |
| dc.title.alternative | Leishmaniasis cutánea en los Andes peruanos: un estudio epidemiológico de infección e inmunidad | es_PE |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1017/S0950268800057964 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.08 | |
| dc.relation.issn | 1469-4409 |
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