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Tropical spastic paraparesis and HTLV-I infection: clinical and epidemiological study in Lima, Peru

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dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author De Las Casas, César
dc.contributor.author Deza, Luis
dc.contributor.author Cabrera, Juan
dc.contributor.author Castañeda, César
dc.contributor.author Watts, Douglas
dc.date.accessioned 2022-10-10T00:48:55Z
dc.date.available 2022-10-10T00:48:55Z
dc.date.issued 1996
dc.identifier.uri https://hdl.handle.net/20.500.12866/12334
dc.description.abstract A descriptive study was performed to investigate the epidemiology and clinical features of 50 patients with tropical spastic paraparesis (TSP) associated with HTLV-I infection acquired in Peru. Cases seen at two reference centers in Lima (Alexander von Humboldt Tropical Medicine Institute and Guillermo Almenara National Hospital) between August 1989 and December 1995 are reviewed. All patients had serologic evidence of infection with reactive ELISA tests for HTLV-I, confirmed by positive Western blot assays. The male-female ratio of cases was 1.0:1.78. The mean age at the time of diagnosis was 52.4 years (range: 29 to 73, SD:11.3). A considerable proportion of patients (68%) had lived in Andean regions: this basically due to their native places (48%) because only 8% of cases were referred from these regions. The mean duration of symptoms prior to diagnosis was 4.95 years (range 0.5–22years). The clinical features at diagnosis included progressive spastic paraparesis (100%) associated with sphincter disturbances (77.7%), paresthesia (61.1%) or lumbar pain (44%). The functional status of all patients was impaired at the time of evaluation: 44.1% walked unaided with a ‘scissors-like’ gait, 38% used assist devices for walking, 10% used wheelchairs and 8% were bedridden. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of the Neurological Sciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HTLV-I en_US
dc.subject Tropical Spastic Paraperesis (TSP) en_US
dc.subject Epidemiology en_US
dc.subject Clinical Peru en_US
dc.title Tropical spastic paraparesis and HTLV-I infection: clinical and epidemiological study in Lima, Peru en_US
dc.title.alternative Paraparesia espástica tropical e infección por HTLV-I: estudio clínico y epidemiológico en Lima, Perú es_PE
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/s0022-510x(96)00186-4
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn 1878-5883

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