Universidad Peruana Cayetano Heredia
Effect of salt supplementation on amphotericin Bnephrotoxicity
JavaScript is disabled for your browser. Some features of this site may not work without it.
Mostrar el registro sencillo del ítem
| dc.contributor.author | Llanos Cuentas, Elmer Alejandro | |
| dc.contributor.author | Cieza Zevallos, Javier Antonio | |
| dc.contributor.author | Bernardo, J | |
| dc.contributor.author | Echevarria Zarate, Juan Ignacio | |
| dc.contributor.author | Biaggioni, I | |
| dc.contributor.author | Sabra, R | |
| dc.contributor.author | Branch, R | |
| dc.date.accessioned | 2022-10-10T03:26:11Z | |
| dc.date.available | 2022-10-10T03:26:11Z | |
| dc.date.issued | 1991 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/12338 | |
| dc.description.abstract | It has been suggested that salt loading protects against amphotericin B-induced nephrotoxicity. The influence of saline loading on the nephrotoxic response to amphotericin B (50 mg/dose given i.v. over 4 hr 3 X/week for 10 weeks) was assessed in two groups of ten patients each who were diagnosed with mucocutaneous leishmaniasis. Patients were randomized to receive either 1 liter of 0.9% saline or 1 liter of 5% dextrose in water, administered i.v. over one hour in a double-blinded manner, directly prior to amphotericin B administration. Renal function was monitored on a weekly basis two days after the last dose of amphotericin B. Baseline characteristics were similar in both groups except for a slightly higher serum creatinine concentration (Cr) in the saline group (0.8 +/- 0.05 vs. 0.6 +/- 0.04 mg/dl). Baseline sodium (Na) excretion was relatively high (262 +/- 23 mmol/day in the dextrose group and 224 +/- 17 mmol/day in the saline group). None of the patients sustained an increase in Cr to values greater than 1.7 mg/dl. Although mean Cr remained within normal, there was a significant difference between the two groups over the ten week period, with the dextrose group sustaining a significant increase in Cr and the saline group remaining unchanged. Serum potassium (K) levels fell in both groups necessitating oral K supplementation. The saline group required significantly greater amounts of K supplementation to maintain a normal serum K. Amphotericin B caused a rapid reduction in the acidification ability of the kidney in response to an ammonium chloride load. Under these conditions, the saline group had a poorer ability to acidify the urine. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartofseries | Kidney International | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Salt supplementation | en_US |
| dc.subject | Nephrotoxicity | en_US |
| dc.title | Effect of salt supplementation on amphotericin Bnephrotoxicity | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1038/ki.1991.214 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.07 | |
| dc.relation.issn | 1523-1755 |
Ficheros en el ítem
| Ficheros | Tamaño | Formato | Ver |
|---|---|---|---|
|
No hay ficheros asociados a este ítem. |
|||
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Artículos en revistas indizadas [4988]
Recuperados de bases de datos bibliográficas
Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess
