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Pathophysiology and Epidemiology of Chronic Mountain Sickness

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dc.contributor.author Monge-C, C
dc.contributor.author Arregui, A
dc.contributor.author León-Velarde, Fabiola
dc.date.accessioned 2022-10-10T03:26:12Z
dc.date.available 2022-10-10T03:26:12Z
dc.date.issued 1992
dc.identifier.uri https://hdl.handle.net/20.500.12866/12344
dc.description.abstract Chronic mountain sickness, which affects permanent residents of high altitudes, is the outcome of a progressive loss of ventilatory rate which naturally occurs with age and resulting in excessive hypoxemia and polycythemia. A theoretical model predicts the progressive failure of homeostatic control of the hemoglobin concentration when the values increase above those found at sea level. This is confirmed by lack of feedback mechanism between high altitude erythrocytosis and serum erythropoietin. The results of epidemiological studies are in agreement with the physiological findings. In a male population living at 4,300 m, an increase with age of the prevalences of excessive erythrocytosis (Hb > 213 g/l), blood oxygen saturation <83%, headaches and a high score of symptoms of chronic mountain sickness has been found. The studies suggest the possibility that in addition to an accentuated hypoxemia, the excessive erythrocytosis may also result from an overreaction of the bone marrow to a fixed level of hypoxemia in ageing individuals. en_US
dc.language.iso eng
dc.publisher Thieme Gruppe
dc.relation.ispartofseries International Journal of Sports and Exercise Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject High altitude natives en_US
dc.subject Polycythemia en_US
dc.subject Erythropoietin en_US
dc.title Pathophysiology and Epidemiology of Chronic Mountain Sickness en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1055/s-2007-1024603
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.11
dc.relation.issn 0172-4622


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