Effects of cocaine on oxygen consumption and mitochondrial respiration in normoxic and hypoxic mice

dc.contributor.author	León-Velarde, Fabiola
dc.contributor.author	Huicho Oriundo, Luis
dc.contributor.author	Monge-C,Carlos
dc.date.accessioned	2022-10-10T03:26:44Z
dc.date.available	2022-10-10T03:26:44Z
dc.date.issued	1992
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12356
dc.description.abstract	The administration of cocaine hydrochloride intraperitoneally (25 mg/kg) produces a drop in VO2 in both normoxic and hypoxic mice. The critical PO2 is also decreased and so is the body temperature. The mitochondrial respiration shows a large fall in ST3 and RCR. The addition of cocaine in-vitro to the incubating medium induces changes in the mitochondrial respiration similar to those found after in-vivo administration. This report shows that in addition to its in-vivo actions cocaine alters the respiratory function of the isolated liver mitochondria.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Life Sciences
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Cocaine	en_US
dc.subject	Mitochondrial respiration	en_US
dc.subject	Normoxic and hypoxic mice	en_US
dc.title	Effects of cocaine on oxygen consumption and mitochondrial respiration in normoxic and hypoxic mice	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/0024-3205(92)90274-S
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn	0024-3205

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