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Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon

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dc.contributor.author Villasis Mayuri, Elizabeth Melisa
dc.contributor.author Garcia Castillo, Stefano S.
dc.contributor.author Guzman Guzman, Mitchel Anthony
dc.contributor.author Torres, Julian
dc.contributor.author Gomez, Joaquin
dc.contributor.author Garro, Katherine
dc.contributor.author Cordova, Ana Maria
dc.contributor.author Reategui, Carolina
dc.contributor.author Abanto, Caroline
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Torres Fajardo, Katherine Jessica
dc.date.accessioned 2022-10-12T18:25:58Z
dc.date.available 2022-10-12T18:25:58Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12374
dc.description.abstract Introduction: Herein, we tested the hypothesis that Asymptomatic P. vivax (Pv) infected individuals (Asym) feature different epidemiological, clinical and biochemical characteristics, as well as hematological parameters, potentially predictive of clinical immunity in comparison to symptomatic Pv infected individuals (Sym). Methodology: Between 2018 - 2021, we conducted 11 population screenings (PS, Day 0 (D0)) in 13 different riverine communities around Iquitos city, in the Peruvian Amazon, to identify Pv Sym and Asym individuals. A group of these individuals agreed to participate in a nested case - control study to evaluate biochemical and hematological parameters. Pv Asym individuals did not present common malaria symptoms (fever, headache, and chills), had a positive/negative microscopy result, a positive qPCR result, reported no history of antimalarial treatment during the last month, and were followed-up weekly until Day 21 (D21). Control individuals, had a negative malaria microscopy and qPCR result, no history of antimalarial treatment or malaria infections during the last three years, and no history of comorbidities or chronic infections. Results: From the 2159 individuals screened during PS, data revealed a low but heterogeneous Pv prevalence across the communities (11.4%), where most infections were Asym (66.7%) and submicroscopic (82.9%). A total of 29 Asym, 49 Sym, and 30 control individuals participated in the nested case - control study (n=78). Ten of the individuals that were initially Asym at D0, experienced malaria symptoms during follow up and therefore, were included in the Sym group. 29 individuals remained Asym throughout all follow-ups. High levels of eosinophils were found in Asym individuals in comparison to Sym and controls. Conclusion: For the first-time, key epidemiological, hematological, and biochemical features are reported from Pv Asym infections from the Peruvian Amazon. These results should be considered for the design and reshaping of malaria control measures as the country moves toward malaria elimination. en_US
dc.language.iso eng
dc.publisher Frontiers Media
dc.relation.ispartofseries Frontiers in Cellular and Infection Microbiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject asymptomatic en_US
dc.subject infection en_US
dc.subject P. vivax en_US
dc.subject parasitemia en_US
dc.subject biochemical en_US
dc.subject hematological en_US
dc.subject parameters en_US
dc.title Epidemiological characteristics of P. vivax asymptomatic infections in the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fcimb.2022.901423
dc.relation.issn 2235-2988


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