Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru.

Shope, Robert E; Palermo, Pedro M; Sharp, Trueman W; Russell, Kevin L; Porter, Kevin R; Morrison, Amy C; Guevara, Carolina; Kochel, Tad J; Hayes, Curtis G; Aguilar, Patricia; Vinetz, Joseph Michael; Guzman, Hilda; de Rosa, Amelia Travassos; Block, Karla; Gotuzzo Herencia, José Eduardo; Wooster, Mark T; Calampa, Carlos; Weaver, Scott C; Watts, Douglas M; Tesh, Robert B; Bautista, Christian T

dc.contributor.author	Watts, Douglas M
dc.contributor.author	Russell, Kevin L
dc.contributor.author	Wooster, Mark T
dc.contributor.author	Sharp, Trueman W
dc.contributor.author	Morrison, Amy C
dc.contributor.author	Kochel, Tad J
dc.contributor.author	Bautista, Christian T
dc.contributor.author	Block, Karla
dc.contributor.author	Guevara, Carolina
dc.contributor.author	Aguilar, Patricia
dc.contributor.author	Palermo, Pedro M
dc.contributor.author	Calampa, Carlos
dc.contributor.author	Porter, Kevin R
dc.contributor.author	Hayes, Curtis G
dc.contributor.author	Weaver, Scott C
dc.contributor.author	de Rosa, Amelia Travassos
dc.contributor.author	Vinetz, Joseph Michael
dc.contributor.author	Shope, Robert E
dc.contributor.author	Gotuzzo Herencia, José Eduardo
dc.contributor.author	Guzman, Hilda
dc.contributor.author	Tesh, Robert B
dc.date.accessioned	2022-10-12T18:25:58Z
dc.date.available	2022-10-12T18:25:58Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12375
dc.description.abstract	The objective of this study was to determine the etiology of febrile illnesses among patients from October 1, 1993 through September 30, 1999, in the urban community of Iquitos in the Amazon River Basin of Peru. Epidemiological and clinical data as well as blood samples were obtained from consenting patients at hospitals, health clinics and private residences. Samples were tested for arboviruses in cell cultures and for IgM and IgG antibodies by ELISA. Blood smears were examined for malaria, and sera were tested for antibodies to Leptospira spp. by ELISA and microscopic agglutination. Among 6,607 febrile patients studied, dengue viruses caused 14.6% of the cases, and Venezuelan equine encephalitis virus caused 2.5%, Oropouche virus 1.0%, Mayaro virus 0.4%, and other arboviruses caused 0.2% of the cases. Also, 22.9% of 4,844 patients tested were positive for malaria, and of 400 samples tested, 9% had evidence of acute leptospirosis. Although the study was not designed to assess the importance of these pathogens as a cause of human morbidity in the total population, these results indicate that arboviruses, leptospirosis, and malaria were the cause of approximately 50% of the febrile cases. Although the arboviruses that were diagnosed can produce asymptomatic infections, our findings increased the overall understanding of the relative health burden of these infections, as well as baseline knowledge needed for designing and implementing further studies to better assess the health impact and threat of these pathogens in the Amazon Basin of Peru.	en_US
dc.language.iso	eng
dc.publisher	American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Etiologies	en_US
dc.subject	Febrile Illnesses	en_US
dc.subject	Iquitos	en_US
dc.subject	Amazon River Basin	en_US
dc.subject	Peru	en_US
dc.title	Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru.	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.22-0259
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645