Universidad Peruana Cayetano Heredia
Late-onset opportunistic infections while receiving anti-retroviral therapy in Latin America: burden and risk factors
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| dc.contributor.author | Núñez, I. | |
| dc.contributor.author | Crabtree-Ramirez, B. | |
| dc.contributor.author | Shepherd, B.E. | |
| dc.contributor.author | Sterling, T.R. | |
| dc.contributor.author | Cahn, P. | |
| dc.contributor.author | Veloso, V.G. | |
| dc.contributor.author | Cortes, C.P. | |
| dc.contributor.author | Padgett, D. | |
| dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
| dc.contributor.author | Sierra-Madero, J. | |
| dc.contributor.author | McGowan, C.C. | |
| dc.contributor.author | Person, A.K. | |
| dc.contributor.author | Caro-Vega, Y. | |
| dc.date.accessioned | 2022-10-12T18:25:59Z | |
| dc.date.available | 2022-10-12T18:25:59Z | |
| dc.date.issued | 2022 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/12383 | |
| dc.description.abstract | Objectives: The aim of this study was to describe the incidence, clinical characteristics, and risk factors of late-onset opportunistic infections (LOI) in people who live with HIV (PWLHA) within the Caribbean, Central and South America network for HIV epidemiology. Methods: We performed a retrospective cohort study including treatment-naive PWLHA enrolled at seven sites (Argentina, Brazil, Chile, Peru, Mexico, and two sites in Honduras). Follow-up began at 6 months after treatment started. Outcomes were LOI, loss to follow-up, and death. We used a Cox proportional hazards model and a competing risks model to evaluate risk factors. Results: A total of 10,583 patients were included. Median follow up was at 5.4 years. LOI occurred in 895 (8.4%) patients. Median time to opportunistic infection was 2.1 years. The most common infections were tuberculosis (39%), esophageal candidiasis (10%), and Pneumocystis jirovecii (P. jirovecii) pneumonia (10%). Death occurred in 576 (5.4%) patients, and 3021 (28.5%) patients were lost to follow-up. A protease inhibitor–based regimen (hazard ratio 1.25), AIDS-defining events during the first 6 months of antiretroviral-treatment (hazard ratio 2.12), starting antiretroviral-treatment in earlier years (hazard ratio 1.52 for 2005 vs 2010), and treatment switch (hazard ratio 1.31) were associated with a higher risk of LOI. Conclusion: LOI occurred in nearly one in 10 patients. People with risk factors could benefit from closer follow-up. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.relation.ispartofseries | International Journal of Infectious Diseases | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Opportunistic infections | en_US |
| dc.subject | HIV | en_US |
| dc.subject | AIDS | en_US |
| dc.subject | Latin America | en_US |
| dc.subject | Tuberculosis | en_US |
| dc.subject | Cohort studies | en_US |
| dc.title | Late-onset opportunistic infections while receiving anti-retroviral therapy in Latin America: burden and risk factors | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1016/j.ijid.2022.06.041 | |
| dc.relation.issn | 1878-3511 |
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