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DNA thermodynamic pressure: A potential contributor to genome evolution

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dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Guerra Giraldez, Daniel
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.date.accessioned 2022-10-25T19:54:09Z
dc.date.available 2022-10-25T19:54:09Z
dc.date.issued 2002
dc.identifier.uri https://hdl.handle.net/20.500.12866/12455
dc.description.abstract Codon usage bias is a feature of living organisms. The origin of this bias might be explained not only by external factors but also by the nature of the structure of deoxyribonucleic acid (DNA) itself. We have developed a point mutation simulation program of coding sequences, in which nucleotide replacement follows thermodynamic criteria. For this purpose we calculated the hydrogen bond-like and electrostatic energies of non-canonical base pairs in a 5 bp neighbourhood. Although the rate of non-canonical base pair formation is extremely low, such pairs occur with a preference towards a guanine (G) or cytosine (C) rather than an adenine (A) or thymine (T) replacement due to thermodynamic considerations. This feature, according to the simulation program, should result in an increase in the GC content of the genome over evolutionary time. In addition, codon bias towards a higher GC usage is also predicted. DNA sequence analysis of genes of the Trypanosomatidae lineage supported the hypothesis that DNA thermodynamic pressure is a driving force that impels increases in GC content and GC codon bias. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Transactions of the Royal Society of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject leishmaniasis en_US
dc.subject trypanosomiasis en_US
dc.subject Leishmania donovani en_US
dc.subject Leishamania chagasi en_US
dc.subject Trypanosoma brucei en_US
dc.subject Trypanosoma cruzi en_US
dc.subject Crithidia fasciculata en_US
dc.subject codon usage bias en_US
dc.subject DNA thermodynamic pressure en_US
dc.subject genome evolution en_US
dc.title DNA thermodynamic pressure: A potential contributor to genome evolution en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/s0035-9203(02)90046-5
dc.relation.issn 1878-3503


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