From population to genome: Ecogenetics of Leishmania (Viannia) braziliensis and L (V) peruviana

Tibayrenc, M.; DeDoncker, S.; Victoir, K.; LeRay, D.; Arévalo Zelada, Jorge Luis; Llanos Cuentas, Elmer Alejandro; Banuls, A.L.; Dujardin, J.C.

dc.contributor.author	Dujardin, J.C.
dc.contributor.author	Banuls, A.L.
dc.contributor.author	Victoir, K.
dc.contributor.author	DeDoncker, S.
dc.contributor.author	Arévalo Zelada, Jorge Luis
dc.contributor.author	Llanos Cuentas, Elmer Alejandro
dc.contributor.author	Tibayrenc, M.
dc.contributor.author	LeRay, D.
dc.date.accessioned	2022-10-25T19:54:10Z
dc.date.available	2022-10-25T19:54:10Z
dc.date.issued	1995
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12460
dc.description.abstract	The size polymorphism of nine chromosomes, recognized by specific probes, was analysed in populations of Leishmania (Viannia) braziliensis and L. (V.) peruviana from various Peruvian biogeographical units. Interpretation of the polymorphism, by statistical and phenetic methods, led to the identification of five consensus (α- and β-tubulin) and four variable chromosomes. The dynamics of the variable chromosomes were studied. The promoter role of the environment on their polymorphism was indicated by: (1) the discrimination of L. braziliensis (forest) and L. peruviana (Andes) by the size of the chromosome containing the gp63 genes; and (2) the fact that, within L. peruviana, the polymorphism of the variable chromosomes revealed a strong eco-geographical structuring of parasite populations, accompanied by increasing chromosomal dissimilarity along a cline from north to south. The adaptative significance of the polymorphism of the variable chromosomes was suggested by: (1) a correlation between chromosomal polymorphism and phenotype variability (lesion type in patients and virulence in vitro);, and (2) the association between the decrease in size of the gp63-containing chromosome from L. braziliensis to L. peruviana, and a rearrangement of the gp63 genes, probably accompanied by a decrease in their copy number. As chromosomal variation was shown to be more dependant on eco-geographical differences than isoenzymatic variation, chromosome variation and enzyme variation probably differ in adaptative significance.	en_US
dc.language.iso	eng
dc.publisher	Taylor and Francis
dc.relation.ispartofseries	Annals of Tropical Medicine and Parasitology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Genome	en_US
dc.subject	ecogenetics	en_US
dc.subject	Leishmania	en_US
dc.subject	Viannia	en_US
dc.subject	braziliensis	en_US
dc.subject	peruviana	en_US
dc.subject	polymorphism	en_US
dc.title	From population to genome: Ecogenetics of Leishmania (Viannia) braziliensis and L (V) peruviana	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1080/00034983.1995.11813014
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn	0003-4983