Universidad Peruana Cayetano Heredia
Gelatin particle indirect agglutination and enzyme-linked immunosorbent assay for diagnosis of strongyloidiasis using Strongyloides venezuelensis antigen
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| dc.contributor.author | Huaman, Maria Cecilia. | |
| dc.contributor.author | Sato, Y. | |
| dc.contributor.author | Aguilar Olano, José Luis | |
| dc.contributor.author | Terashima, A. | |
| dc.contributor.author | Guerra, Humberto | |
| dc.contributor.author | Gotuzzo Herencia, José Eduardo | |
| dc.contributor.author | Kanbara, H. | |
| dc.date.accessioned | 2022-10-25T19:54:10Z | |
| dc.date.available | 2022-10-25T19:54:10Z | |
| dc.date.issued | 2003 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/12461 | |
| dc.description.abstract | Routine microscopical examination of stool specimens for diagnosis of strongyloidiasis is insensitive and serological methods using Strongyloides stercoralis antigen are at present not available for field studies. We evaluated 2 techniques, enzyme-linked immunosorbent assay (ELISA) and gelatin particle indirect agglutination (GPIA), using an antigen obtained from the rodent parasite, S. venezuelensis. Fifty-four Peruvian patients with different clinical forms of strongyloidiasis were studied: 12 asymptomatic, 31 symptomatic, and 11 hyperinfection cases. Our results demonstrate that both ELISA and GPIA using S. venezuelensis antigen are useful for diagnosis of strongyloidiasis, with sensitivities of 74.1% and 98.2%, respectively and a specificity of 100% for both techniques. We found that GPIA is a highly sensitive test for patients with suspected chronic infection and/or hyperinfection. In the hyperinfection cases, significantly lower concentrations of specific immunoglobulin antibodies and eosinophils (P < 0.001) were found compared with the asymptomatic and symptomatic cases. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Oxford University Press | |
| dc.relation.ispartofseries | Transactions of the Royal Society of Tropical Medicine and Hygiene | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | strongyloidiasisllStrongyloides venezuelensislldiagnosisllgelatin particle indirect agglutination testllenzyme-linked immunosorbent assayllPeru | en_US |
| dc.title | Gelatin particle indirect agglutination and enzyme-linked immunosorbent assay for diagnosis of strongyloidiasis using Strongyloides venezuelensis antigen | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1016/S0035-9203(03)80017-2 | |
| dc.relation.issn | 1878-3503 |
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