Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease.

Erlandson, R. A.; Lieberman, P. H.; Arias-Stella, J. Jr.; Arias-Stella, Javier M.D

dc.contributor.author	Arias-Stella, Javier M.D
dc.contributor.author	Lieberman, P. H.
dc.contributor.author	Erlandson, R. A.
dc.contributor.author	Arias-Stella, J. Jr.
dc.date.accessioned	2022-10-25T19:54:10Z
dc.date.available	2022-10-25T19:54:10Z
dc.date.issued	1986
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12463
dc.description.abstract	Twenty-six verruga peruana nodules were studied. The presence of Factor VHI-related antigen and Ulex europaeus lectin binding, and the ultrastructural finding of rudimentary cell junctions and pinocytotic vesicles establish the endothelial character of the proliferating cells in the verruga nodules. Whereas superficial lesions could show an angiomatoid pattern, deep-situated nodules tended to present a compact type of growth. Electron-microscopic studies have shown that Bartonella bacilliformis was found abundantly in the extracellular spaces in the florid lesions and that no organisms were present in the late, resolving subcutaneous nodules. Although no true intracellular “viable” microorganisms were noted, pseudopods of cytoplasm entrapping one or two bacteria and surrounding matrix substance were seen often. The characteristics of cytoplasmic inclusions previously described in verruga cells as “chlamydozoa” were detailed: The ultrastructure of the inclusions corresponded to endothelial phagocytic cells in which complex invaginations of the cell surface had produced a labyrinth of interconnected channels and vacuoles containing degraded bacteria, extracellular matrix components, or both. We conclude that in light microscopy the finding of Rocha- Lima's inclusions is the only definite morphologic evidence of the presence of bartonella in verruga lesions.	en_US
dc.language.iso	eng
dc.publisher	Wolters Kluwer Health
dc.relation.ispartofseries	American Journal of Surgical Pathology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Histology	en_US
dc.subject	Immunohistochemistry	en_US
dc.subject	Ultrastructure	en_US
dc.subject	Verruga	en_US
dc.subject	Carrion's Disease	en_US
dc.title	Histology, immunohistochemistry, and ultrastructure of the verruga in Carrion's disease.	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1097/00000478-198609000-00002
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.09
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.11
dc.relation.issn	1532-0979