In vitro action of progestogens on sperm migration in human cervical mucus

Laudahn, Gerhard; Kesseru, Esteban; Camacho-Ortega, Pedro; Schopflin, Gisela

dc.contributor.author	Kesseru, Esteban
dc.contributor.author	Camacho-Ortega, Pedro
dc.contributor.author	Laudahn, Gerhard
dc.contributor.author	Schopflin, Gisela
dc.date.accessioned	2022-10-25T19:54:10Z
dc.date.available	2022-10-25T19:54:10Z
dc.date.issued	1975
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12465
dc.description.abstract	The presence of progestogens in the cervical mucus suppresses and arrests sperm penetration. Using the Kremer technique, the effects of in vitro released progesterone, d norgestrel, and cyproterone acetate were studied by inserting silicone rubber threads bearing the respective compounds in capillary tubes containing cervical mucus. Control tubes were fitted with nonmedicated silicone rubber threads. After 24 hr of incubation, the sperm migration test was carried out to evaluate penetration depth, qualitative motility, and proportion of motile forms. Progesterone produced the greatest alterations. Migration was arrested within 30 min, the distance reached was consistently less than 2 cm, and sperm were completely immobile at 24 hr. D norgestrel also exhibited a distinct spermiostatic effect, but it was not as intense as that of progesterone. Cyproterone acetate was practically ineffective during the first 120 min, and produced alterations only in the qualitative and proportional mortility.	en_US
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartofseries	Fertility and Sterility
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	In vitro study	en_US
dc.subject	Cyproterone	en_US
dc.subject	Drug comparison	en_US
dc.subject	Estrus	en_US
dc.subject	Gestagen	en_US
dc.subject	Norgestrel	en_US
dc.subject	Normal human	en_US
dc.subject	Progesterone	en_US
dc.subject	Spermatozoon migration	en_US
dc.subject	Spermatozoon motility	en_US
dc.subject	Uterine cervix mucus	en_US
dc.title	In vitro action of progestogens on sperm migration in human cervical mucus	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1016/s0015-0282(16)40875-7
dc.relation.issn	1556-5653