Universidad Peruana Cayetano Heredia

Plasticity of gp63 gene organization in Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana

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dc.contributor.author Victoir, K.
dc.contributor.author Dujardin, J.C.
dc.contributor.author Dedoncker, S.
dc.contributor.author Barker, D.C.
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Hamers, R.
dc.contributor.author Leray, D.
dc.date.accessioned 2022-10-25T19:54:10Z
dc.date.available 2022-10-25T19:54:10Z
dc.date.issued 1995
dc.identifier.uri https://hdl.handle.net/20.500.12866/12476
dc.description.abstract The genomic organization of gp63 genes in 4 and 7 isolates of Leishmania braziliensis and L. peruviana, respectively was studied by RFLP analysis with 3 restriction enzymes (Bgl I, Sal I and Apa I). Our results showed a marked polymorphism among isolates. Some characters were specific to L. braziliensis or to L. peruviana, and others specific to the respective biogeographical populations of L. peruviana. The average minimum copy number of gp63 genes was found to be higher in L. braziliensis (71) than in L. peruviana (46), suggesting that deletion of gp63 genes might be partially involved in the size decrease of the chromosome bearing gp63 genes, observed between those 2 species (from 700 to 610 kb). Our results may suggest the existence of at least 2 arrays of heterologous gp63 repeats, varying in relative copy number between L. braziliensis and L. peruviana, and among isolates of the latter species. Rearrangement of the gp63 genes was observed during long-term in vitro maintenance of a reference strain of L. braziliensis. These observations document the existence of a dynamic gp63 gene organization in Leishmania of the braziliensis complex. en_US
dc.language.iso eng
dc.publisher Cambridge University Press
dc.relation.ispartofseries Parasitology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject genomic organization en_US
dc.subject Leishmania braziliensis en_US
dc.subject Leishmania peruviana en_US
dc.subject gp63 gene en_US
dc.title Plasticity of gp63 gene organization in Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1017/s0031182000081828
dc.relation.issn 1469-8161


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