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Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator

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dc.contributor.author Arevalo, I.
dc.contributor.author Ward, B.
dc.contributor.author Miller, R.
dc.contributor.author Meng, T.
dc.contributor.author Najar Trujillo, Nestor Enrique
dc.contributor.author Alvarez, Eugenia
dc.contributor.author Matlashewski, G.
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.date.accessioned 2022-10-25T19:54:11Z
dc.date.available 2022-10-25T19:54:11Z
dc.date.issued 2001
dc.identifier.uri https://hdl.handle.net/20.500.12866/12484
dc.description.abstract Treatment failures for leishmaniasis with pentavalent antimonials, including meglumine antimonate, are increasingly common in many endemic areas. Imiquimod (Aldara; 3M Pharmaceuticals) is a novel immune response-activating compound, approved by the United States Food and Drug Administration, that is currently used to treat cervical warts and has been shown to activate macrophage killing of Leishmania species. Therefore, an open-label, prospective study was conducted of combined imiquimod plus meglumine antimonate therapy in 12 patients with cutaneous leishmaniasis who had previously not responded to meglumine antimonate therapy. All of the patients responded well to this combination therapy, and 90% were found to be cured at the 6-month follow-up period. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Clinical Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Drug-Resistant en_US
dc.subject Imiquimod en_US
dc.subject Immunomodulator en_US
dc.title Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1086/324161
dc.relation.issn 1537-6591


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