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Insights into Plasmodium vivax Asymptomatic Malaria Infections and Direct Skin-Feeding Assays to Assess Onward Malaria Transmission in the Amazon

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dc.contributor.author Moreno, Marta
dc.contributor.author Torres Fajardo, Katherine Jessica
dc.contributor.author Tong, Carlos
dc.contributor.author Castillo, Stefano S. Garcia
dc.contributor.author Carrasco Escobar, Gabriel
dc.contributor.author Guedez, Gerson
dc.contributor.author Torres, Lutecio
dc.contributor.author Herrera Varela, Manuela
dc.contributor.author Guerra, Layne
dc.contributor.author Guzman Guzman, Mitchel Anthony
dc.contributor.author Wong, Daniel
dc.contributor.author Ramirez, Roberson
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Conn, Jan E.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Vinetz, Joseph Michael
dc.date.accessioned 2022-11-15T23:04:37Z
dc.date.available 2022-11-15T23:04:37Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12530
dc.description.abstract Understanding the reservoir and infectivity of Plasmodium gametocytes to vector mosquitoes is crucial to align strategies aimed at malaria transmission elimination. Yet, experimental information is scarce regarding the infectivity of Plasmodium vivax for mosquitoes in diverse epidemiological settings where the proportion of asymptomatically infected individuals varies at a microgeographic scale. We measured the transmissibility of clinical and subclinical P. vivax malaria parasite carriers to the major mosquito vector in the Amazon Basin, Nyssorhynchus darlingi (formerly Anopheles). A total of 105 participants with natural P. vivax malaria infection were recruited from a cohort study in Loreto Department, Peruvian Amazon. Four of 18 asymptomatic individuals with P. vivax positivity by blood smear infected colony-grown Ny. darlingi (22%), with 2.6% (19 of 728) mosquitoes infected. In contrast, 77% (44/57) of symptomatic participants were infectious to mosquitoes with 51% (890 of 1,753) mosquitoes infected. Infection intensity was greater in symptomatic infections (mean, 17.8 oocysts/mosquito) compared with asymptomatic infections (mean, 0.28 oocysts/mosquito), attributed to parasitemia/gametocytemia level. Paired experiments (N = 27) using direct skin-feeding assays and direct membrane mosquito-feeding assays showed that infectivity to mosquitoes was similar for both methods. Longitudinal studies with longer follow-up of symptomatic and asymptomatic parasite infections are needed to determine the natural variations of disease transmissibility. en_US
dc.language.iso eng
dc.publisher American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Plasmodium vivax en_US
dc.subject Malaria Infections en_US
dc.subject Malaria Transmission en_US
dc.subject Amazon en_US
dc.title Insights into Plasmodium vivax Asymptomatic Malaria Infections and Direct Skin-Feeding Assays to Assess Onward Malaria Transmission in the Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.21-1217
dc.relation.issn 1476-1645


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