Clinical Course of Children with Campylobacter Gastroenteritis With and Without Co-Infection in Lima, Peru

Denise Riveros-Ramirez, Maribel; Chea-Woo, Elsa; Amaro Munoz, Galo; Ochoa Woodell, Theresa Jean

dc.contributor.author	Amaro Munoz, Galo
dc.contributor.author	Denise Riveros-Ramirez, Maribel
dc.contributor.author	Chea-Woo, Elsa
dc.contributor.author	Ochoa Woodell, Theresa Jean
dc.date.accessioned	2022-11-15T23:04:37Z
dc.date.available	2022-11-15T23:04:37Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/20.500.12866/12535
dc.description.abstract	This study describes the clinical course of gastroenteritis caused by Campylobacter spp. as a single-infection versus coinfection and the corresponding changes that occur according to the treatment received, in children between 12 and 24 months of age. This descriptive study is based on the data of a pediatric cohort conducted between 2008 and 2011 of 555 children in Lima, Peru. Ninety-six diarrheal episodes with positive cultures for Campylobacter spp. were evaluated. In 52 episodes, empirical antibiotic treatment was started before pathogen isolation. Of these 96 episodes, 64.6% were coinfections with other pathogens. Coinfections were led by Escherichia coli, norovirus, and Giardia. Compared with single-infection episodes, coinfections had a mean symptom duration of 6.6 versus 5.7 days, a mean frequency of bowel movements per episode of 18.9 versus 14.8, and occurrence of vomiting and fever in 24.2% versus 14.7% of patients. Most of the patients with more severe clinical features at diagnosis were prescribed macrolides as empiric treatment. In the single-infection group, symptom duration was 7.2 +/- 3.3 days in the macrolide-treated group and 7.9 +/- 2.7 days in the nonmacrolide group. Diarrhea caused by coinfection appeared to be generally more severe than a single-pathogen. Patients with more severe clinical courses who received macrolides treatment might have had a faster recovery than patients who received nonmacrolides.	en_US
dc.language.iso	eng
dc.publisher	American Journal of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	Children	en_US
dc.subject	Campylobacter Gastroenteritis	en_US
dc.subject	Lima	en_US
dc.subject	Peru	en_US
dc.title	Clinical Course of Children with Campylobacter Gastroenteritis With and Without Co-Infection in Lima, Peru	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.21-0881
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645