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Sleep and Breathing Disturbances in Children With Leigh Syndrome: A Comparative Study

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dc.contributor.author Wang, Jia-Der Ju
dc.contributor.author Chen, Maida
dc.contributor.author Zhang, Cristian
dc.contributor.author Parker, Jessica
dc.contributor.author Saneto, Russell
dc.contributor.author Ramirez, Jan-Marino
dc.date.accessioned 2022-11-15T23:04:39Z
dc.date.available 2022-11-15T23:04:39Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12571
dc.description.abstract Background: Leigh syndrome (LS) is a progressive neurodegenerative mitochondrial disease character-ized by necrotizing lesions affecting different parts of the central nervous system, especially in the brainstem and basal ganglia. Lesions in this area may involve respiratory and sleep centers, resulting in the clinically significant disturbances seendbut poorly characterizeddin LS. The purpose of the present study is to characterize and compare the physiologic responses to respiratory disturbances quantified by polysomnography metrics of children with LS with age -sex-and apnea-hypopnea index (AHI)-matched patients with obstructive sleep apnea (OSA), a common clinical population with similar burden of sleep -disordered breathing.Methods: Retrospective comparative study of polysomnographic data from six patients with LS were reviewed and compared with 18 age-sex-AHI-matched patients with OSA, with particular attention to cardiorespiratory and sleep architecture metrics.Results: Sleep architecture and stage duration were conserved in LS and OSA groups, but increased wake after sleep onset was seen among the first group. The LS group exhibited both obstructive and central sleep apnea. The group also had significantly greater values of heart rate, >= 3% oxygen desaturation index, and lower values of sleep efficiency, respiratory arousal index, and total sleep time when compared with the OSA group.Conclusions: Patients with LS exhibited significantly more sleep-related cardiorespiratory disturbances and sleep fragmentation when compared with neurotypical children with OSA. Given that these findings are plausibly detrimental to health and development, sleep evaluation in patients with similar conditions should be encouraged for early management. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Pediatric Neurology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Leigh syndrome en_US
dc.subject Sleep en_US
dc.subject Polysomnography en_US
dc.subject Obstructive sleep apnea en_US
dc.subject Central sleep apnea en_US
dc.title Sleep and Breathing Disturbances in Children With Leigh Syndrome: A Comparative Study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.pediatrneurol.2022.08.006
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn 1873-5150


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