Universidad Peruana Cayetano Heredia

Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil

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dc.contributor.author Villalva-Serra, Klauss
dc.contributor.author Barreto-Duarte, Beatriz
dc.contributor.author Nunes, Vanessa M.
dc.contributor.author Menezes, Rodrigo C.
dc.contributor.author Rodrigues, Moreno M. S.
dc.contributor.author Queiroz, Artur T. L.
dc.contributor.author Arriaga, Maria B.
dc.contributor.author Cordeiro-Santos, Marcelo
dc.contributor.author Kritski, Afranio L.
dc.contributor.author Sterling, Timothy R.
dc.contributor.author Araujo-Pereira, Mariana
dc.contributor.author Andrade, Bruno B.
dc.date.accessioned 2022-11-15T23:04:40Z
dc.date.available 2022-11-15T23:04:40Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12577
dc.description.abstract Background: Tuberculosis (TB) is a worldwide public health problem, especially in countries that also report high numbers of people living with HIV (PLWH) and/or diabetes mellitus (DM). However, the unique features of persons with TB-HIV-DM are incompletely understood. This study compared anti-TB treatment (ATT) outcomes of diabetic and non-diabetic TB/HIV co-infected patients. Methods: A nationwide retrospective observational investigation was performed with data from the Brazilian Tuberculosis Database System among patients reported to have TB-HIV co-infection between 2014 and 2019. This database includes all reported TB cases in Brazil. Exploratory and association analyses compared TB treatment outcomes in DM and non-DM patients. Unfavorable outcomes were defined as death, treatment failure, loss to follow-up or recurrence. Multivariable stepwise logistic regressions were used to identify the variables associated with unfavorable ATT outcomes in the TB-HIV population. Results: Of the 31,070 TB-HIV patients analyzed, 999 (3.2%) reported having DM. However, in these TB-HIV patients, DM was not associated with any unfavorable treatment outcome [adjusted Odds Ratio (aOR): 0.97, 95% CI: 0.83–1.12, p = 0.781]. Furthermore, DM was also not associated with any specific type of unfavorable outcome in this study. In both the TB-HIV group and the TB-HIV-DM subpopulation, use of alcohol, illicit drugs and tobacco, as well as non-white ethnicity and prior TB were all characteristics more frequently observed in persons who experienced an unfavorable ATT outcome. Conclusion: DM is not associated with unfavorable TB treatment outcomes in persons with TB-HIV, including death, treatment failure, recurrence and loss to follow up. However, consumption habits, non-white ethnicity and prior TB are all more frequently detected in those with unfavorable outcomes in both TB-HIV and TB-HIV-DM patients. en_US
dc.language.iso eng
dc.publisher Frontiers Media
dc.relation.ispartofseries Frontiers in Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HIV en_US
dc.subject tuberculosis en_US
dc.subject treatment outcome en_US
dc.subject diabetes en_US
dc.subject Antiretroviral therapy (ART) en_US
dc.title Tuberculosis treatment outcomes of diabetic and non-diabetic TB/HIV co-infected patients: A nationwide observational study in Brazil en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fmed.2022.972145
dc.relation.issn 2296-858X


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