Universidad Peruana Cayetano Heredia

Shotgun metagenomics of fecal samples from children in Peru reveals frequent complex co-infections with multiple Campylobacter species

Mostrar el registro sencillo del ítem

dc.contributor.author Parker, Craig T.
dc.contributor.author Schiaffino Salazar, Francesca
dc.contributor.author Huynh, Steven
dc.contributor.author Paredes Olortegui, Maribel
dc.contributor.author Penataro Yori, Pablo
dc.contributor.author Garcia Bardales, Paul F.
dc.contributor.author Pinedo Vasquez, Tackeshy
dc.contributor.author Curico Huansi, Greisi E.
dc.contributor.author Manzanares Villanueva, Katia
dc.contributor.author Shapiama Lopez, Wagner V.
dc.contributor.author Cooper, Kerry K.
dc.contributor.author Kosek, Margaret N.
dc.date.accessioned 2022-11-15T23:04:41Z
dc.date.available 2022-11-15T23:04:41Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12593
dc.description.abstract Campylobacter spp. are a major cause of bacterial diarrhea worldwide and are associated with high rates of mortality and linear growth faltering in children living in low- to middle-income countries (LMICs). Campylobacter jejuni and Campylobacter coli are most often the causative agents of enteric disease among children in LMICs. However, previous work on a collection of stool samples from children under 2 years of age, living in a low resource community in Peru with either acute diarrheal disease or asymptomatic, were found to be qPCR positive for Campylobacter species but qPCR negative for C. jejuni and C. coli. The goal of this study was to determine if whole-genome shotgun metagenomic sequencing (WSMS) could identify the Campylobacter species within these samples. The Campylobacter species identified in these stool samples included C. jejuni, C. coli, C. upsaliensis, C. concisus, and the potential new species of Campylobacter, "Candidatus Campylobacter infans". Moreover, WSMS results demonstrate that over 65% of the samples represented co-infections with multiple Campylobacter species present in a single stool sample, a novel finding in human populations. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Campylobacter en_US
dc.subject Metagenomics en_US
dc.subject Genomics en_US
dc.subject Shotgun sequencing en_US
dc.subject Microbiome en_US
dc.subject Campylobacter jejuni en_US
dc.subject Polymerase chain reaction en_US
dc.subject Ribosomal RNA en_US
dc.title Shotgun metagenomics of fecal samples from children in Peru reveals frequent complex co-infections with multiple Campylobacter species en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0010815
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas