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The SLICC-FI Predicts Damage Accrual in SLE Patients. Data From the Almenara Lupus Cohort

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dc.contributor.author Elera-Fitzcarrald, Claudia
dc.contributor.author Gamboa-Cardenas, Rocio, V.
dc.contributor.author Reategui-Sokolova, Cristina
dc.contributor.author Pimentel Quiroz, Víctor Roman
dc.contributor.author Rodriguez-Bellido, Zoila
dc.contributor.author Pastor-Asurza, Cesar A.
dc.contributor.author Perich-Campos, Risto
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Ugarte Gil, Manuel Francisco
dc.date.accessioned 2022-11-15T23:04:41Z
dc.date.available 2022-11-15T23:04:41Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12595
dc.description.abstract Objective To evaluate the Systemic Lupus International Collaborating Clinics Frailty Index (SLICC-FI) as a predictor of damage accrual in a primarily Mestizo SLE patient cohort. Methods Patients from a single-center prevalent cohort were included. Damage accrual was defined as the increase in the SLICC/American College of Rheumatology (ACR) damage index (SDI) scores between the baseline and the last visits. The SLICC-FI was measured at baseline. Univariable and multivariable Cox regression models were performed to determine the association between the baseline SLICC-FI (per 0.05 increase) and the increase in the SDI, adjusted for possible confounders. Alternative analyses using negative binomial regression models including the difference between the last and the first SDI as outcome were performed. Results Of the 265 patients included, 248 (93.6%) were female with mean (SD) age of 35.1 (13.6) years at diagnosis. At baseline, mean (SD) SLE disease duration was 7.3 (6.5) years, SDI was 1.0 (1.2) and the SLICC-FI was 0.22 (0.05). After a mean (SD) of 5.2 (2.2) years of follow-up, the SDI increased in 126 (47.5%) patients, and the final mean (SD) SDI score was 1.7 (1.7). Higher SLICC-FI scores at baseline predicted greater damage accrual in the univariable analysis [Hazard Ratio (HR) =1.38, (CI95% 1.16-1.65); p < 0.001] and in the multivariable model, after adjustment for possible confounders [HR = 1.30 (CI95% 1.02-1.66); p = 0.033]. Conclusion SLICC-FI predicts the occurrence of damage accrual in a prevalent SLE Latin-American cohort with short or long disease duration, supporting the relevance of this index in the evaluation of SLE patients. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Lupus
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject SLICC-FI en_US
dc.subject SLE Patients en_US
dc.subject Almenara Lupus Cohort en_US
dc.title The SLICC-FI Predicts Damage Accrual in SLE Patients. Data From the Almenara Lupus Cohort en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1177/09612033221126855
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1477-0962


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