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Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon

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dc.contributor.author Villena, Fredy E.
dc.contributor.author Sanchez, Juan F.
dc.contributor.author Nolasco, Oscar
dc.contributor.author Braga, Greys
dc.contributor.author Ricopa, Leonila
dc.contributor.author Barazorda, Keare
dc.contributor.author Salas, Carola J.
dc.contributor.author Lucas, Carmen
dc.contributor.author Lizewski, Stephen E.
dc.contributor.author Joya, Christie A.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Delgado Ratto, Christopher
dc.contributor.author Valdivia, Hugo O.
dc.date.accessioned 2022-11-15T23:04:42Z
dc.date.available 2022-11-15T23:04:42Z
dc.date.issued 2022
dc.identifier.uri https://hdl.handle.net/20.500.12866/12607
dc.description.abstract Malaria is a major health problem in Peru despite substantial progress achieved by the ongoing malaria elimination program. This study explored the population genetics of 63 Plasmodium falciparum and 170 P. vivax cases collected in the Peruvian Amazon Basin between 2015 and 2019. Microscopy and PCR were used for malaria detection and positive samples were genotyped at neutral and drug resistance-associated regions. The P. falciparum population exhibited a low nucleotide diversity (π = 0.02) whereas the P. vivax population presented a higher genetic diversity (π = 0.34). All P. falciparum samples (n = 63) carried chloroquine (CQ) resistant mutations on Pfcrt. Most P. falciparum samples (53 out of 54) carried sulfadoxine (SD) resistant mutations on Pfdhfr and Pfdhps. No evidence was found of artemisinin resistance mutations on kelch13. Population structure showed that a single cluster accounted for 93.4% of the P. falciparum samples whereas three clusters were found for P. vivax. Our study shows a low genetic diversity for both species with significant differences in genetic sub-structuring. The high prevalence of CQ-resistance mutations could be a result of indirect selection pressures driven by the P. vivax treatment scheme. These results could be useful for public health authorities to safeguard the progress that Peru has achieved towards malaria elimination. en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Scientific Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Parasite genomics en_US
dc.subject Population genetics en_US
dc.title Drug resistance and population structure of Plasmodium falciparum and Plasmodium vivax in the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41598-022-21028-3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.07
dc.relation.issn 2045-2322


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